ID K4I8E5_YEASX Unreviewed; 224 AA.
AC K4I8E5;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase {ECO:0000256|ARBA:ARBA00022272};
DE EC=5.3.1.24 {ECO:0000256|ARBA:ARBA00012572};
GN Name=Trp1 {ECO:0000313|EMBL:AFU61176.1};
OS Saccharomyces cerevisiae (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=4932 {ECO:0000313|EMBL:AFU61176.1};
RN [1] {ECO:0000313|EMBL:AFU61176.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wyeast1007 {ECO:0000313|EMBL:AFU61176.1};
RX PubMed=22949655; DOI=10.1073/pnas.1213449109;
RA Kelly A.C., Shewmaker F.P., Kryndushkin D., Wickner R.B.;
RT "Sex, prions, and plasmids in yeast.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:E2683-E2690(2012).
RN [2] {ECO:0000313|EMBL:AFU61176.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wyeast1007 {ECO:0000313|EMBL:AFU61176.1};
RA Cotter K.A., Callard G.V.;
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 3/5. {ECO:0000256|ARBA:ARBA00004664}.
CC -!- SIMILARITY: Belongs to the TrpF family.
CC {ECO:0000256|ARBA:ARBA00007571}.
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DR EMBL; JX468136; AFU61176.1; -; Genomic_DNA.
DR UniPathway; UPA00035; UER00042.
DR GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00405; PRAI; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR HAMAP; MF_00135; PRAI; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001240; PRAI_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR InterPro; IPR044643; TrpF_fam.
DR PANTHER; PTHR42894; N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE; 1.
DR PANTHER; PTHR42894:SF1; N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE; 1.
DR Pfam; PF00697; PRAI; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 3: Inferred from homology;
FT DOMAIN 25..221
FT /note="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)"
FT /evidence="ECO:0000259|Pfam:PF00697"
SQ SEQUENCE 224 AA; 24133 MW; 03353B85FBA8B3BD CRC64;
MSVINFTGSS GPLVKVCGLQ STEAAECALD SDADLLGIIC VPNRKRTIDP VIARKISSLV
KAYKNSSGTP KYLVGVFRNQ PKEDVLALVN DYGIDIVQLH GDESWQEYQE FLGLPVIKRL
VFPKDCNILL SAASQKPHSF IPLFDSEAGG TGELLDWNSI SDWVGRQESP ESLHFMLAGG
LTPENVGDAL RLNGVIGVDV SGGVETNGVK DXNKIANXVK NAKK
//
