ID K4IKY2_BIFAP Unreviewed; 1346 AA.
AC K4IKY2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=BAST_0415 {ECO:0000313|EMBL:AFU71009.1};
OS Bifidobacterium asteroides (strain PRL2011).
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=1147128 {ECO:0000313|EMBL:AFU71009.1, ECO:0000313|Proteomes:UP000007006};
RN [1] {ECO:0000313|EMBL:AFU71009.1, ECO:0000313|Proteomes:UP000007006}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PRL2011 {ECO:0000313|EMBL:AFU71009.1,
RC ECO:0000313|Proteomes:UP000007006};
RX PubMed=23028506; DOI=10.1371/journal.pone.0044229;
RA Bottacini F., Milani C., Turroni F., Sanchez B., Foroni E., Duranti S.,
RA Serafini F., Viappiani A., Strati F., Ferrarini A., Delledonne M.,
RA Henrissat B., Coutinho P., Fitzgerald G.F., Margolles A., van Sinderen D.,
RA Ventura M.;
RT "Bifidobacterium asteroides PRL2011 genome analysis reveals clues for
RT colonization of the insect gut.";
RL PLoS ONE 7:E44229-E44229(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP003325; AFU71009.1; -; Genomic_DNA.
DR RefSeq; WP_015021448.1; NC_018720.1.
DR STRING; 1147128.BAST_0415; -.
DR GeneID; 41009689; -.
DR KEGG; bast:BAST_0415; -.
DR PATRIC; fig|1147128.3.peg.424; -.
DR eggNOG; COG0210; Bacteria.
DR eggNOG; COG2887; Bacteria.
DR HOGENOM; CLU_003630_0_0_11; -.
DR Proteomes; UP000007006; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 2..423
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 424..770
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 211..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 23..30
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1346 AA; 147754 MW; 610B36915FFAB4CC CRC64;
MKQTAEQSAI VDADVNEDLL VVAGAGSGKT MTMTSRIIAL IRRGVPSEQI LGLTFTRKAA
SELQSRVGSA VIRRDQGRGT SGVDPERNFL KPTVSTYDAF FQSIVRQYGL LVGMDQDTRP
LSSAGAYQLA SQVVADHLDL IFPAGASAQD GDSGDLGSAT FSTTVNRVLG LTGAVTTSMI
SSDCPDFDQA VDRIRAWDRV FVDRADQLIG DQPVPATEPR VSQTPPKRSK KETDEHYQGK
IKDFQDTRRS IRIYRVDAMR RAVLTREKLL TLVQDYQRAK RRANMAEFGD FTLAAFQLVE
RFPSISAQLR RRYSHVFLDE YQDTSTTQAL LLAAIFHPHN RQEDQGSEDQ APGRSAVTAV
GDPFQSIYAW RGASPGAFRT FQAQFGMLAD RPDFGGGPLS GVTAFGRSQD QDPLTLSRTF
RNSGWVLKAA NQLTVPLRHR GRESRSEAEL REVDVAKLRP REDADPGTVG LLGYATGGQE
IDGVVRFALR ARELYGNQGD APHVAVLFRS KAALPRYREA MEAAGLSCQV VGYSSLFDRP
EVMDLRALLS LVCDHTDSDS LMRLLASARF GMDAADLSAL ASLAAKVNED SQYRALVRAG
LVESDSDPRR RREDLHRYRD QVPNDVFLVD LLLRDDLPDL LKSSGLSARG RVLAAEAARV
VCQVQAESSA PLRQVVIAAI RALNLDVDLV LARSLADPER PLEPSQAKAG IQALLDQVDV
YLSELPQGIG PSLRGFVSWL SSLDQSPEMP TDGDDRQADV ALMTVHQAKG LEWDAVAVVG
LKRGAFPSSQ GDRLTVKPAL DQPVVQSPDG PVYQYNCTAR TWLVDPESVP VPVRADAMIL
PRFPHDAPLG ADPEDLLGRL DLASLEEEAT GLSRESWLDD QAQPVRADAI APSQREQYGR
RLLDDERRLI YVAATRARHD LLLTFSQDSQ AESAALNTPA PDPDKASNFW TELVELFQEE
PEAVKLEQAE DAQEGEPTPP LGLFVGENAQ SYRQAVVDQA LEEVDQVAAR DGGRDQALWP
PVLSARTREA LNRSASWVRA GKPGDPVIDE EGDDGLYANA VRVLQVSTGR LGVANDQLLT
DLDLLRRTGR RILGHGASSV TAIQAGSAGG DPKMERDYWQ GLVRPIPQVA SPQAEAGTRF
HDWARRFILP EISAPQGLVD LPDQAEAPNL LDGPLGPGAM AERARMLAGL DRERESMDSQ
ADPVQARLLT WEQRLAESEW AQRTPVWVER PIVAVLAGRI VKGKLDAVFA GGLDPDRPDL
HYTIVDWKTG SRPRGEDSTN RRLVQLDFYR LLLSRLEGIG LSTIDACLYY VSEDRPQDRL
IRARARTEEE ILASMAEGIP EQSDED
//
