ID K4JG63_9HYPO Unreviewed; 535 AA.
AC K4JG63;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 08-NOV-2023, entry version 29.
DE RecName: Full=DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00012418};
DE EC=2.7.7.6 {ECO:0000256|ARBA:ARBA00012418};
DE Flags: Fragment;
GN Name=RPB1 {ECO:0000313|EMBL:AFU81846.1};
OS Neonectria galligena.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Neonectria.
OX NCBI_TaxID=56674 {ECO:0000313|EMBL:AFU81846.1};
RN [1] {ECO:0000313|EMBL:AFU81846.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRRL 20487 {ECO:0000313|EMBL:AFU81846.1};
RX PubMed=23357352; DOI=10.1016/j.fgb.2012.12.004;
RA O'Donnell K., Rooney A.P., Proctor R.H., Brown D.W., McCormick S.P.,
RA Ward T.J., Frandsen R.J., Lysoe E., Rehner S.A., Aoki T., Robert V.A.,
RA Crous P.W., Groenewald J.Z., Kang S., Geiser D.M.;
RT "Phylogenetic analyses of RPB1 and RPB2 support a middle Cretaceous origin
RT for a clade comprising all agriculturally and medically important
RT fusaria.";
RL Fungal Genet. Biol. 52:20-31(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JX171475; AFU81846.1; -; Genomic_DNA.
DR AlphaFoldDB; K4JG63; -.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 6.20.50.80; -; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR007075; RNA_pol_Rpb1_6.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF37; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR Pfam; PF04992; RNA_pol_Rpb1_6; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..130
FT /note="RNA polymerase Rpb1"
FT /evidence="ECO:0000259|Pfam:PF04983"
FT DOMAIN 157..261
FT /note="RNA polymerase Rpb1"
FT /evidence="ECO:0000259|Pfam:PF05000"
FT DOMAIN 268..535
FT /note="RNA polymerase Rpb1"
FT /evidence="ECO:0000259|Pfam:PF04998"
FT DOMAIN 334..518
FT /note="RNA polymerase Rpb1"
FT /evidence="ECO:0000259|Pfam:PF04992"
FT COILED 137..164
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFU81846.1"
FT NON_TER 535
FT /evidence="ECO:0000313|EMBL:AFU81846.1"
SQ SEQUENCE 535 AA; 59539 MW; 8CF5100B68803385 CRC64;
FLTKDEVMNQ MLWLPNWDGI IPQPAILKPQ PRWTGKQIIS MVIPKEVSLH TAPDSKEDNP
INDEGLLIQS GHLMYGLLTK KYVGAAAGGI IHVSYNELGP QGAMAFLNGV QQVVTHWLLQ
TGHSIGIGDT IPDKATIEKV QVHIDEEKAE VARLTAQATA NELEALPGMN VRATFENKVS
MALNQARDKA GTTTQKSLKD SNNAVTMASS GSKGSSINIS QMTALVGQQI VEGKRIPFGF
KYRTLPHFTK DDYSPEARGF VENSYLRGLT PSEFFFHAMA GREGLIDTAV KTAETGYIQR
RLVKALEDLS ARYDGTVRNS LGDVVQFLYG EDGLDAMCIE KQKLGILNMS DAAFEQKYRL
DLANPPDWFK KDYEYGNELT GDKPSMALLD SEWDALLSDR RVVRRINKSK MNEEMMQLPL
HIGRVIESAK RVFNVKANDR SNLRPSDVIV SIQEMLAKMK IVRGKDPISD EADANATILW
KALVRSRLSF KEIVKEHRLN KLAFDHILGE LLNRWDRAFV SPGEMVGVLA AQSIG
//
