ID K4PXV1_9FLAV Unreviewed; 659 AA.
AC K4PXV1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE Flags: Fragment;
OS dengue virus type 3.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC Amarillovirales; Flaviviridae; Orthoflavivirus; Orthoflavivirus denguei;
OC Dengue virus.
OX NCBI_TaxID=11069 {ECO:0000313|EMBL:BAM63302.1};
RN [1] {ECO:0000313|EMBL:BAM63302.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=D3/JKTA44/88 {ECO:0000313|EMBL:BAM63302.1};
RX PubMed=22959957; DOI=10.1016/j.meegid.2012.08.006;
RA Sjatha F., Takizawa Y., Yamanaka A., Konishi E.;
RT "Phylogenetic analysis of dengue virus types 1 and 3 isolated in Jakarta,
RT Indonesia in 1988.";
RL Infect. Genet. Evol. 12:1938-1943(2012).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Host endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004153}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004153}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004385}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004385}.
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DR EMBL; AB600929; BAM63302.1; -; Genomic_RNA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR CDD; cd12149; Flavi_E_C; 1.
DR CDD; cd17038; Flavi_M; 1.
DR Gene3D; 1.20.1280.260; -; 1.
DR Gene3D; 2.60.40.350; -; 1.
DR Gene3D; 1.10.8.970; Flavivirus envelope glycoprotein M-like; 1.
DR Gene3D; 2.60.260.50; Flavivirus polyprotein propeptide domain; 1.
DR Gene3D; 2.60.98.10; Tick-borne Encephalitis virus Glycoprotein, domain 1; 1.
DR Gene3D; 3.30.67.10; Viral Envelope Glycoprotein, domain 2; 1.
DR Gene3D; 3.30.387.10; Viral Envelope Glycoprotein, domain 3; 1.
DR InterPro; IPR000069; Env_glycoprot_M_flavivir.
DR InterPro; IPR038302; Env_glycoprot_M_sf_flavivir.
DR InterPro; IPR013755; Flav_gly_cen_dom_subdom1.
DR InterPro; IPR027287; Flavi_E_Ig-like.
DR InterPro; IPR026470; Flavi_E_Stem/Anchor_dom.
DR InterPro; IPR038345; Flavi_E_Stem/Anchor_dom_sf.
DR InterPro; IPR011998; Flavi_Glycoprot_E_cen/dimer.
DR InterPro; IPR002535; Flavi_propep.
DR InterPro; IPR038688; Flavi_propep_sf.
DR InterPro; IPR000336; Flavivir/Alphavir_Ig-like_sf.
DR InterPro; IPR036253; Glycoprot_cen/dimer_sf.
DR InterPro; IPR038055; Glycoprot_E_dimer_dom.
DR InterPro; IPR013756; GlyE_cen_dom_subdom2.
DR InterPro; IPR014756; Ig_E-set.
DR NCBIfam; TIGR04240; flavi_E_stem; 1.
DR Pfam; PF21659; Flavi_E_stem; 1.
DR Pfam; PF02832; Flavi_glycop_C; 1.
DR Pfam; PF00869; Flavi_glycoprot; 1.
DR Pfam; PF01004; Flavi_M; 1.
DR Pfam; PF01570; Flavi_propep; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF56983; Viral glycoprotein, central and dimerisation domains; 1.
PE 4: Predicted;
KW Clathrin-mediated endocytosis of virus by host
KW {ECO:0000256|ARBA:ARBA00022570};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Fusion of virus membrane with host endosomal membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Fusion of virus membrane with host membrane
KW {ECO:0000256|ARBA:ARBA00022506};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host endoplasmic reticulum {ECO:0000256|ARBA:ARBA00023184};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virus endocytosis by host {ECO:0000256|ARBA:ARBA00022890};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT TRANSMEM 608..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..90
FT /note="Flavivirus polyprotein propeptide"
FT /evidence="ECO:0000259|Pfam:PF01570"
FT DOMAIN 93..165
FT /note="Envelope glycoprotein M flavivirus"
FT /evidence="ECO:0000259|Pfam:PF01004"
FT DOMAIN 168..460
FT /note="Envelope glycoprotein E central and dimerisation"
FT /evidence="ECO:0000259|Pfam:PF00869"
FT DOMAIN 462..557
FT /note="Glycoprotein E immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF02832"
FT DOMAIN 560..654
FT /note="Flavivirus envelope glycoprotein E Stem/Anchor"
FT /evidence="ECO:0000259|Pfam:PF21659"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAM63302.1"
FT NON_TER 659
FT /evidence="ECO:0000313|EMBL:BAM63302.1"
SQ SEQUENCE 659 AA; 72267 MW; D7E88A15B079DD57 CRC64;
FHLTSRDGEP RMIVGKNERG KSLLFKTASG INMCTLIAMD LGEMCDDTVT YKCPLITEVE
PEDIDCWCNL TSTWVTYGTC NQAGEHRRDK RSVALAPHVG MGLDTRTQTW MSAEGAWRQV
EKVETWAFRH PGFTVLALFL AHYIGTSLTQ KVVIFILLML VTPSMTMRCV GVGNRDFVEG
LSGATWVDVV LEHGGCVTTM AKNKPTLDIE LQKTEATQLA TLRKLCIEGK ITNVTTDSRC
PTQGEAILPE EQDQNYVCKH TYVDRGWGNG CGLFGKGSLV TCAKFQCLES IEGKVVQHEN
LKYTVIITVH TGDQHQVGNE TQGVTAEITP QASTVEAILP EYGTLGLECS PRTGLDFNEM
ILLTMKNKAW MVHRQWFFDL PLPWTSGATT ETPTWNKKEL LVTFKNAHAK KQEVVVLGSQ
EGAMHTALTG ATEIQTSGGI SIFAGHLKCR LKMDKLELKG MSYAMCLNAF VLKKEVSETQ
HGTILIKVEY KGEDAPCKIP FSTEDGQGKA HNGRLITANP VVTKKEEPVN IEAEPPFGES
NIVIGIGDKA LKINWYKKGS SIGKMFEATA RGARRMAILG DTAWDFGSVG GVLNSLGKMV
HQIFGSAYTA LFSGVSWIMK IGIGVLLTWI GLNSKNTSMS FSCIVIGIIT LYLGAVVQA
//
