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Database: UniProt
Entry: K4ZHI0_PAEAL
LinkDB: K4ZHI0_PAEAL
Original site: K4ZHI0_PAEAL 
ID   K4ZHI0_PAEAL            Unreviewed;       451 AA.
AC   K4ZHI0;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   05-JUL-2017, entry version 33.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EJW18819.1};
GN   ORFNames=PAV_2c05870 {ECO:0000313|EMBL:EJW18819.1};
OS   Paenibacillus alvei DSM 29.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae;
OC   Paenibacillus.
OX   NCBI_TaxID=1206781 {ECO:0000313|EMBL:EJW18819.1, ECO:0000313|Proteomes:UP000006321};
RN   [1] {ECO:0000313|EMBL:EJW18819.1, ECO:0000313|Proteomes:UP000006321}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 29 {ECO:0000313|EMBL:EJW18819.1,
RC   ECO:0000313|Proteomes:UP000006321};
RX   PubMed=23105091; DOI=10.1128/JB.01698-12;
RA   Djukic M., Becker D., Poehlein A., Voget S., Daniel R.;
RT   "Genome Sequence of Paenibacillus alvei DSM 29, a Secondary Invader
RT   during European Foulbrood Outbreaks.";
RL   J. Bacteriol. 194:6365-6365(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EJW18819.1}.
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DR   EMBL; AMBZ01000002; EJW18819.1; -; Genomic_DNA.
DR   RefSeq; WP_005545462.1; NZ_AMBZ01000002.1.
DR   EnsemblBacteria; EJW18819; EJW18819; PAV_2c05870.
DR   PATRIC; fig|1206781.3.peg.1989; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000006321; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006321};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006321}.
FT   DOMAIN      144    272       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      356    425       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     152    159       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   451 AA;  51452 MW;  F442768A2A931794 CRC64;
     MERQANEHWQ EILSVIQTKL SKPSFDTWFK ATKAVKFTDS QLLITAPNTF SVEWLESRYT
     KLVSSTVMEE TGKQVDVKFI IEEAAQAEAE IVQPQASPAR VAVYDEPASN MLNPKYTFDT
     FVIGSNNRFA HAASLAVAEA PAKAYNPLFL YGGVGLGKTH LMHAIGHYIL EHNPASRVVY
     TTSEKFMNEF INAIRDNRGE SFRNKYRNID ILLIDDIQFL AGKEQTQEEF FHTFNALHNE
     NKHIVLSSDR PPKEIETLEE RLRSRFEWGL ITDIQPPDLE TRIAILRKKA KAENLDIPNE
     AMVYIANQIN TNIRELEGAL TRVVAFSTMT NQDITTHLAA EALKDLIPSS RPKMITIQDI
     QHKVGEFYGL KMEDFKARKR TKAVAFPRQI AMYLSRELTD YSLPKIGEAF GGRDHTTVIH
     AHEKITQNLQ EDQDLYKVVQ NLIDKIKNPT L
//
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