ID K5B9N8_MYCHD Unreviewed; 357 AA.
AC K5B9N8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=2,4-diaminopentanoate dehydrogenase {ECO:0000313|EMBL:VCT92218.1};
DE EC=1.4.1.12 {ECO:0000313|EMBL:VCT92218.1};
DE SubName: Full=Dihydrodipicolinate reductase, family protein {ECO:0000313|EMBL:EKF25773.1};
GN Name=ord_13 {ECO:0000313|EMBL:VCT92218.1};
GN ORFNames=C731_0261 {ECO:0000313|EMBL:EKF25773.1}, MHAS_03945
GN {ECO:0000313|EMBL:VCT92218.1};
OS Mycolicibacterium hassiacum (strain DSM 44199 / CIP 105218 / JCM 12690 /
OS 3849) (Mycobacterium hassiacum).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1122247 {ECO:0000313|EMBL:EKF25773.1, ECO:0000313|Proteomes:UP000006265};
RN [1] {ECO:0000313|EMBL:EKF25773.1, ECO:0000313|Proteomes:UP000006265}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 {ECO:0000313|EMBL:EKF25773.1}, and DSM 44199 / CIP
RC 105218 / JCM 12690 / 3849 {ECO:0000313|Proteomes:UP000006265};
RX PubMed=23209251; DOI=10.1128/JB.01880-12;
RA Tiago I., Maranha A., Mendes V., Alarico S., Moynihan P.J., Clarke A.J.,
RA Macedo-Ribeiro S., Pereira P.J., Empadinhas N.;
RT "Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of
RT heat-stable mycobacterial proteins.";
RL J. Bacteriol. 194:7010-7011(2012).
RN [2] {ECO:0000313|EMBL:VCT92218.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mhassiacum {ECO:0000313|EMBL:VCT92218.1};
RA Peiro R., Begona, Cbmso G., Lopez M., Gonzalez S., Sacristan E.,
RA Castillo E.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000268660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 / CIP 105218 / JCM 12690 / 3849
RC {ECO:0000313|Proteomes:UP000268660};
RX PubMed=30701245; DOI=10.1128/mra.01522-18;
RA Sanchez M., Blesa A., Sacristan-Horcajada E., Berenguer J.;
RT "Complete genome sequence of Mycolicibacterium hassiacum DSM 44199.";
RL Microbiol. Resour. Announc. 8:e01522-e01522(2019).
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DR EMBL; AMRA01000009; EKF25773.1; -; Genomic_DNA.
DR EMBL; LR026975; VCT92218.1; -; Genomic_DNA.
DR RefSeq; WP_005623636.1; NZ_LR026975.1.
DR AlphaFoldDB; K5B9N8; -.
DR STRING; 1122247.GCA_000379865_01852; -.
DR KEGG; mhas:MHAS_03945; -.
DR PATRIC; fig|1122247.3.peg.245; -.
DR eggNOG; COG3804; Bacteria.
DR OrthoDB; 4759936at2; -.
DR Proteomes; UP000006265; Unassembled WGS sequence.
DR Proteomes; UP000268660; Chromosome 1.
DR GO; GO:0047530; F:2,4-diaminopentanoate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0008839; F:4-hydroxy-tetrahydrodipicolinate reductase; IEA:InterPro.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR045760; DAP_DH_C.
DR InterPro; IPR000846; DapB_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF19328; DAP_DH_C; 1.
DR Pfam; PF01113; DapB_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:VCT92218.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006265}.
FT DOMAIN 12..76
FT /note="Dihydrodipicolinate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01113"
FT DOMAIN 138..347
FT /note="2,4-diaminopentanoate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19328"
SQ SEQUENCE 357 AA; 38243 MW; 3385CD583ABF9696 CRC64;
MPNTYRVVQW TTGNVGKSSV EAIVRHPNYE LVGVYAWSKD KVGRDAGELA GIEPLGITAT
DDIDALLALK PDVVVYNPMW INVDELVRIL EAGVNVVATA SFITGHNLGA DRDRIEQAAK
RGGATIFGSG VSPGFAELLA IVSATACDRV DKITISESAD TTLYDSPDTE RPVGFGTPID
DPNLAPMASK GTAVFAEAVR LVADSLGLQL DEIVCEAEYA KTTEDLDLGS WRIDAGCVAG
VYVSWQGRIG GRTVIDLNVR WRKGQSLEPD WQLDGDGWKI TVEGRPTINM QVGFLPPPDM
IENAKSIEDF FVLGHIMTAM PPIHAIPAVV AAPPGIATYN DLPLPQARGV VPVQQNA
//
