ID K5B9S0_MYCHD Unreviewed; 491 AA.
AC K5B9S0;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Penicillin-binding protein A {ECO:0000313|EMBL:EKF25933.1};
GN Name=pbpA {ECO:0000313|EMBL:EKF25933.1};
GN ORFNames=C731_0053 {ECO:0000313|EMBL:EKF25933.1}, MHAS_04206
GN {ECO:0000313|EMBL:VCT92478.1};
OS Mycolicibacterium hassiacum (strain DSM 44199 / CIP 105218 / JCM 12690 /
OS 3849) (Mycobacterium hassiacum).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1122247 {ECO:0000313|EMBL:EKF25933.1, ECO:0000313|Proteomes:UP000006265};
RN [1] {ECO:0000313|EMBL:EKF25933.1, ECO:0000313|Proteomes:UP000006265}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 {ECO:0000313|EMBL:EKF25933.1}, and DSM 44199 / CIP
RC 105218 / JCM 12690 / 3849 {ECO:0000313|Proteomes:UP000006265};
RX PubMed=23209251; DOI=10.1128/JB.01880-12;
RA Tiago I., Maranha A., Mendes V., Alarico S., Moynihan P.J., Clarke A.J.,
RA Macedo-Ribeiro S., Pereira P.J., Empadinhas N.;
RT "Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of
RT heat-stable mycobacterial proteins.";
RL J. Bacteriol. 194:7010-7011(2012).
RN [2] {ECO:0000313|EMBL:VCT92478.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mhassiacum {ECO:0000313|EMBL:VCT92478.1};
RA Peiro R., Begona, Cbmso G., Lopez M., Gonzalez S., Sacristan E.,
RA Castillo E.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000268660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 / CIP 105218 / JCM 12690 / 3849
RC {ECO:0000313|Proteomes:UP000268660};
RX PubMed=30701245; DOI=10.1128/mra.01522-18;
RA Sanchez M., Blesa A., Sacristan-Horcajada E., Berenguer J.;
RT "Complete genome sequence of Mycolicibacterium hassiacum DSM 44199.";
RL Microbiol. Resour. Announc. 8:e01522-e01522(2019).
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMRA01000002; EKF25933.1; -; Genomic_DNA.
DR EMBL; LR026975; VCT92478.1; -; Genomic_DNA.
DR RefSeq; WP_005623138.1; NZ_LR026975.1.
DR AlphaFoldDB; K5B9S0; -.
DR STRING; 1122247.GCA_000379865_00742; -.
DR KEGG; mhas:MHAS_04206; -.
DR PATRIC; fig|1122247.3.peg.50; -.
DR eggNOG; COG0768; Bacteria.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000006265; Unassembled WGS sequence.
DR Proteomes; UP000268660; Chromosome 1.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF24; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PBPA; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006265};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..491
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033700780"
FT DOMAIN 160..482
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 491 AA; 51542 MW; B2A135ED605A998A CRC64;
MNTSLRRVAV TVMALVVVLL ANATFTQVFT ADGLRSDPRN QRVLLDEYSR QRGQISAGGQ
LLAYSVATSG RFRFLRVYPD PLIYAPVTGF YSLRYSSTGL ERAEDSILNG SDQRLFARRL
ADFFTGRDPR GGNVDTTIKP HVQQAAWEAM ETGCDGPCKG AVVAIEPSTG RILALVTSPS
YDPNLLATHD VDAQAQAWQQ LRDDPDMPLL NRAIAEAYPP GSTFKVITTA AALQHGETPD
TRLTAAPRIR LPNSTASLEN FGGASCGGGP TASLKEAFAR SCNTAFVELG IGLGADALRS
TARAFGIDVP APTIPLQVAE STVGPIIDDA ALGMSAIGQK DVALTPLQNA MVAATIANKG
VTMRPYLVES LRGPDLANIA TTAPEQERRA VSEQVADTLT DLMVAAEQGT QQKGAIAGVQ
IASKTGTAEH GTDPRNTPPH AWYIAFAPAQ APKVAVAVLV ENGGNRLSAT GGAVAAPIGR
ATIAAALREG S
//
