ID K5VVC1_AGABU Unreviewed; 534 AA.
AC K5VVC1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 03-MAY-2023, entry version 41.
DE RecName: Full=aldehyde dehydrogenase (NAD(+)) {ECO:0000256|ARBA:ARBA00024226};
DE EC=1.2.1.3 {ECO:0000256|ARBA:ARBA00024226};
GN ORFNames=AGABI1DRAFT_114711 {ECO:0000313|EMBL:EKM78424.1};
OS Agaricus bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627 / FGSC
OS 10392) (White button mushroom).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Agaricus.
OX NCBI_TaxID=597362 {ECO:0000313|EMBL:EKM78424.1, ECO:0000313|Proteomes:UP000008493};
RN [1] {ECO:0000313|Proteomes:UP000008493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JB137-S8 / ATCC MYA-4627 / FGSC 10392
RC {ECO:0000313|Proteomes:UP000008493};
RX PubMed=23045686; DOI=10.1073/pnas.1206847109;
RA Morin E., Kohler A., Baker A.R., Foulongne-Oriol M., Lombard V., Nagy L.G.,
RA Ohm R.A., Patyshakuliyeva A., Brun A., Aerts A.L., Bailey A.M.,
RA Billette C., Coutinho P.M., Deakin G., Doddapaneni H., Floudas D.,
RA Grimwood J., Hilden K., Kuees U., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lucas S.M., Murat C., Riley R.W., Salamov A.A., Schmutz J., Subramanian V.,
RA Woesten H.A.B., Xu J., Eastwood D.C., Foster G.D., Sonnenberg A.S.,
RA Cullen D., de Vries R.P., Lundell T., Hibbett D.S., Henrissat B.,
RA Burton K.S., Kerrigan R.W., Challen M.P., Grigoriev I.V., Martin F.;
RT "Genome sequence of the button mushroom Agaricus bisporus reveals
RT mechanisms governing adaptation to a humic-rich ecological niche.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:17501-17506(2012).
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR EMBL; JH971392; EKM78424.1; -; Genomic_DNA.
DR RefSeq; XP_007331076.1; XM_007331014.1.
DR AlphaFoldDB; K5VVC1; -.
DR STRING; 597362.K5VVC1; -.
DR GeneID; 18824438; -.
DR KEGG; abp:AGABI1DRAFT114711; -.
DR eggNOG; KOG2453; Eukaryota.
DR HOGENOM; CLU_005391_1_2_1; -.
DR InParanoid; K5VVC1; -.
DR OMA; DAWKVYM; -.
DR OrthoDB; 8449at2759; -.
DR Proteomes; UP000008493; Unassembled WGS sequence.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR CDD; cd07130; ALDH_F7_AASADH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR044638; ALDH7A1-like.
DR PANTHER; PTHR43521; ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43521:SF1; ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000008493}.
FT DOMAIN 54..513
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 284
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 534 AA; 56802 MW; D0026852D4936DBA CRC64;
MLSIARQTIR NQSRVSTRAL STRASTILSK LDIDASAEVH GVYDGQWGGS GEIVVSRCPT
TGEELARVRT ASKEELREAL ARTREAYTIF RNVPAPKRGE LVRQVREALS AKRDDLGALV
TLEMGKILTE GVGEVQEFVD ICDYAVGLSR MMNGSFIASE RPEHSILHVP NPLGVVAVLS
AFNFPVAVYG WNLALSMAAG NATIWKPSPT TPLCSIAITK IISRVLEANG IPGAVASLVT
GDKDVGAPLV NDPGVELVSF TGSERVGRIV GQAVMSRFGK TILELGGNNA SIVMPDADLS
LAVPAVGFGA IGTAGQRCTS TRRLYLHRSV AGEFLERLEK LYKSIKPGDP LESKTLLGPL
HTHAACGIYS QAVDHLKSIG SELLVGGKAY DSAPFKGGNF VEPTISVHKS VNKSDSVWTT
EVFAPILNVG IFDELDQAIE WNNAVPQGLS SSLWTRDLRN VGKWIGPSGS DTGIVNVNVG
TSGAEIGAPF GGNKSTGWGR ESGGDAWKQY VRWSACTINF SNEAPLAQGV NFSA
//
