ID K5X8N3_AGABU Unreviewed; 830 AA.
AC K5X8N3;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=AGABI1DRAFT_74345 {ECO:0000313|EMBL:EKM79367.1};
OS Agaricus bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627 / FGSC
OS 10392) (White button mushroom).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Agaricus.
OX NCBI_TaxID=597362 {ECO:0000313|EMBL:EKM79367.1, ECO:0000313|Proteomes:UP000008493};
RN [1] {ECO:0000313|Proteomes:UP000008493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JB137-S8 / ATCC MYA-4627 / FGSC 10392
RC {ECO:0000313|Proteomes:UP000008493};
RX PubMed=23045686; DOI=10.1073/pnas.1206847109;
RA Morin E., Kohler A., Baker A.R., Foulongne-Oriol M., Lombard V., Nagy L.G.,
RA Ohm R.A., Patyshakuliyeva A., Brun A., Aerts A.L., Bailey A.M.,
RA Billette C., Coutinho P.M., Deakin G., Doddapaneni H., Floudas D.,
RA Grimwood J., Hilden K., Kuees U., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lucas S.M., Murat C., Riley R.W., Salamov A.A., Schmutz J., Subramanian V.,
RA Woesten H.A.B., Xu J., Eastwood D.C., Foster G.D., Sonnenberg A.S.,
RA Cullen D., de Vries R.P., Lundell T., Hibbett D.S., Henrissat B.,
RA Burton K.S., Kerrigan R.W., Challen M.P., Grigoriev I.V., Martin F.;
RT "Genome sequence of the button mushroom Agaricus bisporus reveals
RT mechanisms governing adaptation to a humic-rich ecological niche.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:17501-17506(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR EMBL; JH971390; EKM79367.1; -; Genomic_DNA.
DR RefSeq; XP_007329779.1; XM_007329717.1.
DR AlphaFoldDB; K5X8N3; -.
DR STRING; 597362.K5X8N3; -.
DR GeneID; 18831176; -.
DR KEGG; abp:AGABI1DRAFT74345; -.
DR eggNOG; KOG0926; Eukaryota.
DR HOGENOM; CLU_001832_0_0_1; -.
DR InParanoid; K5X8N3; -.
DR OMA; KYAYHCA; -.
DR OrthoDB; 5490433at2759; -.
DR Proteomes; UP000008493; Unassembled WGS sequence.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17982; DEXHc_DHX37; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008493}.
FT DOMAIN 12..190
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 299..475
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 260..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 92538 MW; B4DEB4EC9E94559C CRC64;
MLPVVTEEQP IMEAIMLNPV VIICGETGSG KTTQVPQFLH EAGFGNSDGD NPGMIGITQP
RRVAAISMAK RVGYELSLTS SQVSHQIRYD ATVSSSTSIK FMTDGVLLRE LATDFLLSKY
SVIIIDEAHE RSINTDILIG VLSRVIKLRE EMWKEDKEGT KPLRLVIMSA TLRISDFSEN
KSLFSVSPPT VNIAVRQHPV TVHFSRRTPA DYVTEAIKKA SKIHTRLPPG GILIFLTGQN
EITGVCRRLE ERYGRKALKR KQKDRLNRTS TGEQKFRQSD ERTHKLIVNP TQADVEAEDI
DNDVEDFAPV DERFDGDAAE EYRDDLESEG DEDLDNELGI DTEVPMHIVP LYSLLSSEKQ
MDVFNPPPPD SRLVVVATNV AETSVTIPGI KYVVDCGRMK ERRYDVANGI HAFQITWISK
ASAAQRAGRA GRTGPGHCYR LYSSALYEHY FQQFNPPEIL RVPVDAIVLQ MKNMHIDAVV
NFPFPTPPDR FALQKAEKVL THLGALKKSS TLTSQLEPVS GQITDLGRTM ALFPLSPRYS
RMLAAGQQHQ CLPYVITIVS AMSVGDPFLH EEAVQVEDDG QTSSETEDVA QLSGGRGMIA
ERNRLRRKAY FEVQREHASL GEFTSDSLKI LSVVGAYEYH GGAGAFCSDH FVRLKAMEEI
HKLRTQLTNI VQMYFPTTNV QFTSKLPPPN KIQIKVLKQL ICAAFIDQVA VRKDLVSHHN
PSSGSQYSNS HGVPYRAVGI SEDVFIHPSS VLWNLPPPNY IVFQEVVRTT RVFVKGLTAV
NPAWLSSLSR ATPLCTYSKP FRAADDVLMV IPRYGPDNWE LPAVKAEGHL
//
