ID K5XF42_AGABU Unreviewed; 1403 AA.
AC K5XF42;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=RhoGAP-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AGABI1DRAFT_118900 {ECO:0000313|EMBL:EKM81832.1};
OS Agaricus bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627 / FGSC
OS 10392) (White button mushroom).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Agaricus.
OX NCBI_TaxID=597362 {ECO:0000313|EMBL:EKM81832.1, ECO:0000313|Proteomes:UP000008493};
RN [1] {ECO:0000313|Proteomes:UP000008493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JB137-S8 / ATCC MYA-4627 / FGSC 10392
RC {ECO:0000313|Proteomes:UP000008493};
RX PubMed=23045686; DOI=10.1073/pnas.1206847109;
RA Morin E., Kohler A., Baker A.R., Foulongne-Oriol M., Lombard V., Nagy L.G.,
RA Ohm R.A., Patyshakuliyeva A., Brun A., Aerts A.L., Bailey A.M.,
RA Billette C., Coutinho P.M., Deakin G., Doddapaneni H., Floudas D.,
RA Grimwood J., Hilden K., Kuees U., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lucas S.M., Murat C., Riley R.W., Salamov A.A., Schmutz J., Subramanian V.,
RA Woesten H.A.B., Xu J., Eastwood D.C., Foster G.D., Sonnenberg A.S.,
RA Cullen D., de Vries R.P., Lundell T., Hibbett D.S., Henrissat B.,
RA Burton K.S., Kerrigan R.W., Challen M.P., Grigoriev I.V., Martin F.;
RT "Genome sequence of the button mushroom Agaricus bisporus reveals
RT mechanisms governing adaptation to a humic-rich ecological niche.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:17501-17506(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JH971387; EKM81832.1; -; Genomic_DNA.
DR RefSeq; XP_007327647.1; XM_007327585.1.
DR STRING; 597362.K5XF42; -.
DR GeneID; 18825510; -.
DR KEGG; abp:AGABI1DRAFT118900; -.
DR eggNOG; KOG1703; Eukaryota.
DR eggNOG; KOG2710; Eukaryota.
DR HOGENOM; CLU_001321_2_1_1; -.
DR InParanoid; K5XF42; -.
DR OMA; QCSAKFF; -.
DR OrthoDB; 1329523at2759; -.
DR Proteomes; UP000008493; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09391; LIM1_Lrg1p_like; 1.
DR CDD; cd09392; LIM2_Lrg1p_like; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 4.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24215; RHO-GTPASE-ACTIVATING PROTEIN LRG1; 1.
DR PANTHER; PTHR24215:SF10; RHO-GTPASE-ACTIVATING PROTEIN LRG1; 1.
DR Pfam; PF00412; LIM; 2.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00132; LIM; 2.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW LIM domain {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000008493};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 159..219
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 222..282
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 1016..1218
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1260..1403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..761
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1356..1403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1403 AA; 154732 MW; 2A0ED65A20D0583F CRC64;
MSRENDSGQA PSPWASAVIS PNTSSPNAAR PLERPNAPTR SATYGAPDPD RNLSNTRIPQ
SRSEDLNHGV SSSPQSPSYL AASPRPSPAF LSSASSSRPS TPGGALNLKP LSSSGHSDDS
DQHLSVNSHV SGQSASSSQS SAVKQAGSVS TTPTSLASTT CSACGKPMHG QFVRALGSVY
HLDCFKCVDC GEVVALKFFP IEGSDGKQFP LCERDCFRRL NLICAKCGMA LRGSYITACN
KKFHVEHFTC SVCPTLFGPQ DSYYEHEGDI YCHFHYSTRF ATKCAGCSSA ILKQFVEINR
NMRDECWHPE CYMINKFWNV KVVSRRPTSA TGEGESQEPA YVEEERKETA SSLKEKQVRM
EQQVYRIWTV LSAFEESSAA CISDMLRQVS HGQYLDAIRM AEKFILHVEV LFATIDDLEF
HFSQLNMKGM SHVRESRMLC RKTVELFTLL SHTQETGARR MGMTQELLAL VTGLAHYLKI
LIRIALTGAL KLEREQSARE AMTSFLDKLH LLAIPGGNPG ARRMIKGYQE DSSSHGAVNF
GTQGVTYGFR SLAPENAGES PFAPSALRDN RVSSQNPPSD LCVKCNQTVE EDCVRLGTYQ
RWHSNCIQCT VCGKVALIPM LKDQSSKSGD EKDTKENVIP PAKPSSARRP PANVKLFVFD
PDSVVETPSF GEVPKVVYCT EHAQSSCKSG FQPVQRLEQY AFLLNVALRR LYLLLKKQGV
VPLSPVATAH GDQGPPASSD PYRNSEYRRV SNVERKSSAT ARLPKRSTII ESPAGKVAHP
SDLGQSGQRS QESTAQHQYH THQHYQHHAN GNNNALPSSG PRPTQPQQSP QPQQSSSQQD
SLLPYAQPPP SQSSQSPAQS PPQQYAKPNL SKLPIDPPTG QALRPAFSRN NNEVMILEES
APNSPTGGEE NPLGPAKDGK AFSLGDIQSI VEAAQAREQH RSLPRETSLP YISRLDPLEL
ALVKHLAVLA LMRSPLKDSF DLDEILEMVE PKKSGFWQKL FKPDKKNPKK KVVFGERLDI
LVEREGADSL LGASESALRV PSFIDDVISA MRTMDMSVEG IFRKNGNIKR LNATIEAIDR
DPSSVDFTQD NPVQLAALLK KFLGFLPEPL MTFKLHRLFA ASQNLPSDED RKRYLHYISL
IMPKPHRDTM EVIFVFLKWV ASFAHTDSET GNLMDLPNLA TVIAPSIMRA RGRDPVRDET
FGALRVVTNL LEYQDEFFLV PAEFVQVLQD QEYFVNCMEL PGKEFLKKCE TYMKVKGMNG
RPPPSNGLHN GSNGIPRYTP MLASPAVERP SPTLPFVSDS RNRQPLPPQV PHAMQTGVPH
VPDVHGSPGA FSLPQGMTPN VQRAPPNEEW QPPPRMRDPN TSSSRSPSFS DAPRPSLDNT
QASSSSPHLP SSNSYPSAVR QRT
//
