ID K6DTG4_9BACI Unreviewed; 259 AA.
AC K6DTG4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Global transcriptional regulator CodY {ECO:0000256|ARBA:ARBA00034538, ECO:0000256|HAMAP-Rule:MF_00621};
GN Name=codY {ECO:0000256|HAMAP-Rule:MF_00621};
GN ORFNames=BABA_23810 {ECO:0000313|EMBL:EKN64071.1};
OS Neobacillus bataviensis LMG 21833.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Neobacillus.
OX NCBI_TaxID=1117379 {ECO:0000313|EMBL:EKN64071.1, ECO:0000313|Proteomes:UP000006316};
RN [1] {ECO:0000313|EMBL:EKN64071.1, ECO:0000313|Proteomes:UP000006316}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 21833T {ECO:0000313|Proteomes:UP000006316};
RX PubMed=23087684;
RA Heylen K., Keltjens J.;
RT "Redundancy and modularity in membrane-associated dissimilatory nitrate
RT reduction in Bacillus.";
RL Front. Microbiol. 3:371-371(2012).
CC -!- FUNCTION: DNA-binding global transcriptional regulator which is
CC involved in the adaptive response to starvation and acts by directly or
CC indirectly controlling the expression of numerous genes in response to
CC nutrient availability. During rapid exponential growth, CodY is highly
CC active and represses genes whose products allow adaptation to nutrient
CC depletion. {ECO:0000256|HAMAP-Rule:MF_00621}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00621}.
CC -!- SIMILARITY: Belongs to the CodY family. {ECO:0000256|HAMAP-
CC Rule:MF_00621}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKN64071.1}.
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DR EMBL; AJLS01000151; EKN64071.1; -; Genomic_DNA.
DR RefSeq; WP_007087753.1; NZ_AJLS01000151.1.
DR AlphaFoldDB; K6DTG4; -.
DR STRING; 1117379.BABA_23810; -.
DR PATRIC; fig|1117379.3.peg.4939; -.
DR eggNOG; COG4465; Bacteria.
DR OrthoDB; 2056at2; -.
DR Proteomes; UP000006316; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00621; HTH_type_CodY; 1.
DR InterPro; IPR014154; CodY.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR013198; GTP_trans_reg_CodY_C.
DR InterPro; IPR010312; Transc_reg_CodY_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR02787; codY_Gpos; 1.
DR PANTHER; PTHR40062:SF1; GLOBAL TRANSCRIPTIONAL REGULATOR CODY; 1.
DR PANTHER; PTHR40062; GTP-SENSING TRANSCRIPTIONAL PLEIOTROPIC REPRESSOR CODY; 1.
DR Pfam; PF06018; CodY; 1.
DR Pfam; PF08222; HTH_CodY; 1.
DR PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00621};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00621}; Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_00621};
KW Reference proteome {ECO:0000313|Proteomes:UP000006316};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00621};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00621};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00621}.
FT DOMAIN 3..178
FT /note="Global transcriptional regulator CodY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06018"
FT DOMAIN 198..254
FT /note="Global transcriptional regulator CodY C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08222"
FT DNA_BIND 203..222
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00621"
FT REGION 1..155
FT /note="GAF domain"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00621"
FT MOD_RES 215
FT /note="Phosphoserine"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00621"
SQ SEQUENCE 259 AA; 29309 MW; 3AF13CD314846CAB CRC64;
MDLLTKTRKI NILLQKAAGK PVNFKEMSET LSETIEANVY IVSRRGKLLG FSIYQQIENE
RMKKMFEDRQ FPEEYTKGLF NIQETSSNLD IESQYTAFPV ENDELFREGL TTIVPIIGGG
ERLGTLILAR LQEKFHDDDL ILAEYGATVV GMEILREKSE EIEEEARSKA VVQMAISSLS
YSELEAIEHI FEELNGHEGL LVASKIADRV GITRSVIVNA LRKLESAGVI ESRSLGMKGT
YIKVLNDKFL IELDKLRSK
//
