ID   K6I538_9LEPT            Unreviewed;       388 AA.
AC   K6I538;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=3'-5' exonuclease {ECO:0000313|EMBL:EKO78695.1};
DE            EC=3.6.1.- {ECO:0000313|EMBL:EKO78695.1};
GN   ORFNames=LEP1GSC068_2576 {ECO:0000313|EMBL:EKO78695.1};
OS   Leptospira sp. Fiocruz LV3954.
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=1193012 {ECO:0000313|EMBL:EKO78695.1, ECO:0000313|Proteomes:UP000002809};
RN   [1] {ECO:0000313|EMBL:EKO78695.1, ECO:0000313|Proteomes:UP000002809}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fiocruz LV3954 {ECO:0000313|EMBL:EKO78695.1,
RC   ECO:0000313|Proteomes:UP000002809};
RA   Harkins D.M., Durkin A.S., Brinkac L.M., Selengut J.D., Sanka R., DePew J.,
RA   Ko A.I., Reis M.G., Ribeiro G.S., Wunder E.Jr., Vinetz J.M., Sutton G.G.,
RA   Nelson W.C., Fouts D.E.;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKO78695.1}.
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DR   EMBL; AKWV02000035; EKO78695.1; -; Genomic_DNA.
DR   RefSeq; WP_004467527.1; NZ_AKWV02000035.1.
DR   AlphaFoldDB; K6I538; -.
DR   PATRIC; fig|1193012.3.peg.1587; -.
DR   Proteomes; UP000002809; Unassembled WGS sequence.
DR   GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR   CDD; cd06142; RNaseD_exo; 1.
DR   Gene3D; 1.10.150.80; HRDC domain; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR045092; Rrp6-like.
DR   PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR   PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00341; HRDC; 1.
DR   SUPFAM; SSF47819; HRDC-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50967; HRDC; 1.
PE   4: Predicted;
KW   Exonuclease {ECO:0000313|EMBL:EKO78695.1};
KW   Hydrolase {ECO:0000313|EMBL:EKO78695.1};
KW   Nuclease {ECO:0000313|EMBL:EKO78695.1}.
FT   DOMAIN          298..378
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
SQ   SEQUENCE   388 AA;  45236 MW;  1E512C022F1950DF CRC64;
     MQINSDYIVV DTIRSLQLVL INLGQADSLS VDTESSGYYT YFSKVCLIQI SAKGKNYILD
     PLKLRNLDGL GTLFENKKIL KIFHSAIDDI KALKKDFGFQ FQNIADTGFS SRLLDHEQYS
     LTYLVDYYHK IKLSKKEQKS NWEKRPLEKS QLQYAALDTV YLETIWEKMK DELIKRNLYE
     EALSEFEKIA SEEPGGEGNS ISMDKFPEIL EYSADERRFI YDTLVFRDDK SRKLNKAPFR
     VFNNEKVILL VKSRRDMTKL TEIVGKKDAE TLFQIYANPS GPPIQKSELF KKPGENLTNE
     EGERFKRLRI WRETIMSIRR MSHQMMPSNK MIAELAQKNP KTLDELREME LFSEWKVVHY
     GPSILAALEN VPYESNIKGL IPINKKFE
//