ID K6TE48_9CLOT Unreviewed; 674 AA.
AC K6TE48;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=A370_00115 {ECO:0000313|EMBL:EKQ58258.1};
OS Clostridium sp. Maddingley MBC34-26.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1196322 {ECO:0000313|EMBL:EKQ58258.1, ECO:0000313|Proteomes:UP000001325};
RN [1] {ECO:0000313|EMBL:EKQ58258.1, ECO:0000313|Proteomes:UP000001325}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Maddingley MBC34-26 {ECO:0000313|Proteomes:UP000001325};
RX PubMed=23405323;
RA Rosewarne C.P., Greenfield P., Li D., Tran-Dinh N., Bradbury M.I.,
RA Midgley D.J., Hendry P.;
RT "Draft Genome Sequence of Clostridium sp. Maddingley, Isolated from Coal-
RT Seam Gas Formation Water.";
RL Genome Announc. 1:E00081-12(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKQ58258.1}.
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DR EMBL; ALXI01000002; EKQ58258.1; -; Genomic_DNA.
DR AlphaFoldDB; K6TE48; -.
DR STRING; 1196322.A370_00115; -.
DR PATRIC; fig|1196322.3.peg.114; -.
DR eggNOG; COG5002; Bacteria.
DR Proteomes; UP000001325; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR033425; MASE3.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR43547:SF2; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C; 1.
DR PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF17159; MASE3; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001325};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 41..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 421..642
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 255..285
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 674 AA; 78476 MW; 807C0A228BBA1367 CRC64;
MLNLSIKQKQ IIEYTFLALL CFSLYFLSRL NFILFHTSTK LVTIVLGFSL MLIGLGTIKM
SKNNYFHILA IIFGITAFID LLHVLSFKGI NLFNNDFNLS IQLSVLSDYY KCIMLSLSIR
YINKEFNWYK VFLINILIIV FAIVCMVVLD IFPVCYVEGY GFTLFRKISE LICSLFLLVI
LFRVINSEID ILKKNRLELV LAICLQTLSY VCFVLYNNIF GIFGLIGHML NILAYYYGFK
VVFKSIVVNP YTILFQRLNH KVIELEKINK ELNKVNYKAH NMEKLNEKFI NLIPDGILII
RDKKIKSANN RFLNMFSIDN EEKIINMNCS EIIDKPYRDI FEFRMSKMNR SILEKPHQYE
IVCGQIRKWV EITSLIVNDE SGEYIISAIR NIEDRKKAEQ AERLLELKKK EDIMKNEFFT
NISHELRTPI NVIYSALQVE NSYLNNDNTM QPIIKYNKII RQNCLRLIRL VNNIIDITRI
ETSFFKPNYS IENIVSIVEE ITMSIVEYIE SKHINLIFDT EIEEAYVKCD SVLIERIILN
LLSNAVKYGK NNGNIKVYIC QEEENKISIF VKDDGIGIPN EMREKIFDRF LKVDNSLSRK
TEGSGIGLSL VKQLVEIHGG TITFSSELNL GTEFKITLPI VDYCIEACAT IEKTNNYHKN
IIESAEIEFS DIYD
//
