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Database: UniProt
Entry: K6UC97_9APIC
LinkDB: K6UC97_9APIC
Original site: K6UC97_9APIC 
ID   K6UC97_9APIC            Unreviewed;       972 AA.
AC   K6UC97;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   07-JUN-2017, entry version 20.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
DE   Flags: Fragment;
GN   ORFNames=PCYB_012040 {ECO:0000313|EMBL:GAB64471.1};
OS   Plasmodium cynomolgi strain B.
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=1120755 {ECO:0000313|EMBL:GAB64471.1, ECO:0000313|Proteomes:UP000006319};
RN   [1] {ECO:0000313|EMBL:GAB64471.1, ECO:0000313|Proteomes:UP000006319}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B {ECO:0000313|EMBL:GAB64471.1,
RC   ECO:0000313|Proteomes:UP000006319};
RX   PubMed=22863735; DOI=10.1038/ng.2375;
RA   Tachibana S., Sullivan S.A., Kawai S., Nakamura S., Kim H.R., Goto N.,
RA   Arisue N., Palacpac N.M.Q., Honma H., Yagi M., Tougan T., Katakai Y.,
RA   Kaneko O., Mita T., Kita K., Yasutomi Y., Sutton P.L., Shakhbatyan R.,
RA   Horii T., Yasunaga T., Barnwell J.W., Escalante A.A., Carlton J.M.,
RA   Tanabe K.;
RT   "Plasmodium cynomolgi genome sequences provide insight into Plasmodium
RT   vivax and the monkey malaria clade.";
RL   Nat. Genet. 44:1051-1055(2012).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; DF157093; GAB64471.1; -; Genomic_DNA.
DR   RefSeq; XP_004220758.1; XM_004220710.1.
DR   EnsemblProtists; GAB64471; GAB64471; PCYB_012040.
DR   GeneID; 14691060; -.
DR   KEGG; pcy:PCYB_012040; -.
DR   EuPathDB; PlasmoDB:PCYB_012040; -.
DR   KO; K02154; -.
DR   Proteomes; UP000006319; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006319};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006319};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    461    486       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    507    524       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    594    615       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    627    650       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    688    711       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    908    928       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      304    331       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:GAB64471.1}.
SQ   SEQUENCE   972 AA;  111009 MW;  B032FFC9EFB95184 CRC64;
     TMKHGTLVLP SDRAREYLDC LGKNIDIQFI DMNEKTMKRQ YKKYIQRIDD MERILRFLEE
     NIKKLPNVKI KKSKIDSFLE HDNVYELDQV EESLNRLHVQ FVRFCNNNKD LVDERNNAVE
     EKHVILTAMN QLNPDGTKNG NLGKKLPENS IPYDEVNDES VSLQTNMIKD GINMMMFTNI
     SGVIKTKDQE SFSRTIFRAL RGNTYTYFQS IDESAASSMG GGVDGMKDGD EGGGASSSSI
     HNGNDNDDIM DEKNDIDNDK GKNNEPKSVF VVYCQGSSQS NIYHKILKIC KAYDVKTYDW
     PKTYEQARQR LKELKEIITD KEKALKAYEE YFINEIFVLI NVVEPNKNSL IEEWKLFCKK
     ERYIYNSLNC FEGSDITLRC DCWFSANDEE KIRHMLITKS SNDLVSALLL SDKVLTPNIS
     PPTYIKTNKF TKSYQSMVDT YGIPRYGEIN PAISTIITFP FLFGIMYGDV GHGVCLFLFA
     LFLIIINHRI KNKNQNEMVS MLLDGRYMLL LMGFFAIYAG FLYNDFFSMP LNLFTSMFEV
     DKEVDSVIYY KRRKVMNTAS GQMEDANPYI FGFDAKWLGA ENELTYINSF KMKFSIIIGF
     LHMTFGVLMK GLNALHYRRK LDFFFEFLPQ LLMMLSIIGY LVFLIIYKWV TPIGYGGYQK
     QGIINTVINM YLMKDLTAQN QFYAHQGLVQ AFLIAIFVLC IPLMFVCKPA IRTYHIMKEK
     KNGGGLSRGG SYSHHEEKEM THTFNHLVGG GTLVGLHGVV GGVGNGANLA NGGSSAPSLH
     KRSPNVSFPS GGASNNREED YLSPRRRNKP TDDEMEAHLL SPASPEHPDG VAESFGAGSV
     GTNHHEENIS EIWIEQLIET IEFILGLISN TASYLRLWAL SLAHQQLSFV FFEQTILNSL
     KKDSFMSVLI NLIVFSQLFS ILTIAVILCM DTLECFLHSL RLQWVEFQNK FYKGDGIPFR
     PFNIKKLLSE SD
//
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