ID   K6V6K6_9ACTN            Unreviewed;       307 AA.
AC   K6V6K6;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:GAB91843.1};
GN   Name=tyrA {ECO:0000313|EMBL:GAB91843.1};
GN   ORFNames=GORHZ_151_00150 {ECO:0000313|EMBL:GAB91843.1};
OS   Gordonia rhizosphera NBRC 16068.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC   Gordonia.
OX   NCBI_TaxID=1108045 {ECO:0000313|EMBL:GAB91843.1, ECO:0000313|Proteomes:UP000008363};
RN   [1] {ECO:0000313|EMBL:GAB91843.1, ECO:0000313|Proteomes:UP000008363}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 16068 {ECO:0000313|EMBL:GAB91843.1,
RC   ECO:0000313|Proteomes:UP000008363};
RA   Takarada H., Isaki S., Hosoyama A., Tsuchikane K., Katsumata H., Baba S.,
RA   Ohji S., Yamazaki S., Fujita N.;
RT   "Whole genome shotgun sequence of Gordonia rhizosphera NBRC 16068.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAB91843.1}.
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DR   EMBL; BAHC01000151; GAB91843.1; -; Genomic_DNA.
DR   AlphaFoldDB; K6V6K6; -.
DR   STRING; 1108045.GORHZ_151_00150; -.
DR   eggNOG; COG0287; Bacteria.
DR   Proteomes; UP000008363; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR046825; PDH_C.
DR   InterPro; IPR046826; PDH_N.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF20463; PDH_C; 1.
DR   Pfam; PF02153; PDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008363}.
FT   DOMAIN          1..281
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51176"
SQ   SEQUENCE   307 AA;  31981 MW;  9044BE5793E99880 CRC64;
     MIGLGLIGGS LLRALSDGGR SAFGYNRSAQ TVADATAAGY RASDDLVATL RQAASDDAMI
     VLATPVTVID DLLKSIAEYA PNCLLTDVIS VKQPVAQAVA RLAPGMRYVG GHPMAGTSQS
     GWAATDPQLF TDAMWMVTTE DHTRPDDWLA VASMARAVDA YVVPAAPDAH DRAVAAISHL
     PHLTAATTAA VGAGESGLAL RLAAGSFRDG TRVAGTAPAL QRAMLEANGI ALLNVLSEAI
     DRLIAARDEL RDNGTVEILV DDGHRARNAY EAVTGATPAP ITGVVVGEHG WAHELRRQAH
     QARVWIG
//