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Database: UniProt
Entry: K6VEM7_9MICO
LinkDB: K6VEM7_9MICO
Original site: K6VEM7_9MICO 
ID   K6VEM7_9MICO            Unreviewed;       649 AA.
AC   K6VEM7;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   SubName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase {ECO:0000313|EMBL:GAB94653.1};
GN   Name=iolD {ECO:0000313|EMBL:GAB94653.1};
GN   ORFNames=KILIM_008_00080 {ECO:0000313|EMBL:GAB94653.1};
OS   Kineosphaera limosa NBRC 100340.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Dermatophilaceae;
OC   Kineosphaera.
OX   NCBI_TaxID=1184609 {ECO:0000313|EMBL:GAB94653.1, ECO:0000313|Proteomes:UP000008366};
RN   [1] {ECO:0000313|EMBL:GAB94653.1, ECO:0000313|Proteomes:UP000008366}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 100340 {ECO:0000313|EMBL:GAB94653.1,
RC   ECO:0000313|Proteomes:UP000008366};
RA   Yoshida I., Isaki S., Hosoyama A., Tsuchikane K., Katsumata H., Ando Y.,
RA   Ohji S., Hamada M., Tamura T., Yamazoe A., Yamazaki S., Fujita N.;
RT   "Whole genome shotgun sequence of Kineosphaera limosa NBRC 100340.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAB94653.1}.
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DR   EMBL; BAHD01000008; GAB94653.1; -; Genomic_DNA.
DR   RefSeq; WP_006591185.1; NZ_BAHD01000008.1.
DR   AlphaFoldDB; K6VEM7; -.
DR   STRING; 1184609.KILIM_008_00080; -.
DR   eggNOG; COG3962; Bacteria.
DR   OrthoDB; 3194735at2; -.
DR   Proteomes; UP000008366; Unassembled WGS sequence.
DR   GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR   CDD; cd02003; TPP_IolD; 1.
DR   CDD; cd07035; TPP_PYR_POX_like; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR030817; Myo_inos_IolD.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR045229; TPP_enz.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR   PANTHER; PTHR18968:SF9; 3D-(3,5/4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR   PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:GAB94653.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008366};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          83..158
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          246..380
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          443..601
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   649 AA;  69705 MW;  BEF4DF7CDCA94A4A CRC64;
     MTSAGRRTVR LTVAQALVRF LAAQYSERDG VEQRLVPGMF GIFGHGNVAG VGQALLQAQV
     QAEEAGGGQS VTQRPVTDPA DGELPYYMAR NEQGAVNAAA AFAKTTDRLQ ALAVTASIGP
     GSTNMVTGAA LATTNRLPVL LLPSDIFATR YPDPVLQQLE DPRCLDISVN DAFKPVSRFW
     DRINRPEQLI PSALAAMRVL ADPAETGAVT ICLPQDVQAE AYDWPEEFFA RRVWHVARPV
     PEPAALERAL AAIRAAKKPL VVAGGGVIYS GASEVLREFA SATGIPVADT QAGKGAINWD
     HPLAVGGVGS TGNMAANTLA READLVIGVG TRYSDFTTAS HTIFANPDVR FVNVNVLAFD
     AAKHSATMVV ADAREALTAL QAGLAGWRTD EAYQSRAAEL DADWQRVVDE CYHRDQTPLP
     AQTEVFGALN ELMGDTDVVI NAAGSMPGDL QCLWRAKTPQ QYHLEYAFSC MGYEIPAAMG
     VRMAKGEEGQ VVAIVGDGTY QMLPMEIATI VAERLKVIFV LLQNHGYASI GALSESRGSQ
     RFGTKYRMRN AATGRLDGEE VPFDLAANAA SWGATVLRCN GIEEFRENYA KAAAADGPTV
     LYIETDLYGP NPPGSAWWDV PVSQVSELES TQLASKEYEE EKAAQRHYL
//
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