ID K6VEM7_9MICO Unreviewed; 649 AA.
AC K6VEM7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase {ECO:0000313|EMBL:GAB94653.1};
GN Name=iolD {ECO:0000313|EMBL:GAB94653.1};
GN ORFNames=KILIM_008_00080 {ECO:0000313|EMBL:GAB94653.1};
OS Kineosphaera limosa NBRC 100340.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Dermatophilaceae;
OC Kineosphaera.
OX NCBI_TaxID=1184609 {ECO:0000313|EMBL:GAB94653.1, ECO:0000313|Proteomes:UP000008366};
RN [1] {ECO:0000313|EMBL:GAB94653.1, ECO:0000313|Proteomes:UP000008366}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 100340 {ECO:0000313|EMBL:GAB94653.1,
RC ECO:0000313|Proteomes:UP000008366};
RA Yoshida I., Isaki S., Hosoyama A., Tsuchikane K., Katsumata H., Ando Y.,
RA Ohji S., Hamada M., Tamura T., Yamazoe A., Yamazaki S., Fujita N.;
RT "Whole genome shotgun sequence of Kineosphaera limosa NBRC 100340.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAB94653.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BAHD01000008; GAB94653.1; -; Genomic_DNA.
DR RefSeq; WP_006591185.1; NZ_BAHD01000008.1.
DR AlphaFoldDB; K6VEM7; -.
DR STRING; 1184609.KILIM_008_00080; -.
DR eggNOG; COG3962; Bacteria.
DR OrthoDB; 3194735at2; -.
DR Proteomes; UP000008366; Unassembled WGS sequence.
DR GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR CDD; cd02003; TPP_IolD; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR030817; Myo_inos_IolD.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR PANTHER; PTHR18968:SF9; 3D-(3,5/4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:GAB94653.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008366};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 83..158
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 246..380
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 443..601
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 649 AA; 69705 MW; BEF4DF7CDCA94A4A CRC64;
MTSAGRRTVR LTVAQALVRF LAAQYSERDG VEQRLVPGMF GIFGHGNVAG VGQALLQAQV
QAEEAGGGQS VTQRPVTDPA DGELPYYMAR NEQGAVNAAA AFAKTTDRLQ ALAVTASIGP
GSTNMVTGAA LATTNRLPVL LLPSDIFATR YPDPVLQQLE DPRCLDISVN DAFKPVSRFW
DRINRPEQLI PSALAAMRVL ADPAETGAVT ICLPQDVQAE AYDWPEEFFA RRVWHVARPV
PEPAALERAL AAIRAAKKPL VVAGGGVIYS GASEVLREFA SATGIPVADT QAGKGAINWD
HPLAVGGVGS TGNMAANTLA READLVIGVG TRYSDFTTAS HTIFANPDVR FVNVNVLAFD
AAKHSATMVV ADAREALTAL QAGLAGWRTD EAYQSRAAEL DADWQRVVDE CYHRDQTPLP
AQTEVFGALN ELMGDTDVVI NAAGSMPGDL QCLWRAKTPQ QYHLEYAFSC MGYEIPAAMG
VRMAKGEEGQ VVAIVGDGTY QMLPMEIATI VAERLKVIFV LLQNHGYASI GALSESRGSQ
RFGTKYRMRN AATGRLDGEE VPFDLAANAA SWGATVLRCN GIEEFRENYA KAAAADGPTV
LYIETDLYGP NPPGSAWWDV PVSQVSELES TQLASKEYEE EKAAQRHYL
//