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Database: UniProt
Entry: K6VSL6_9ACTN
LinkDB: K6VSL6_9ACTN
Original site: K6VSL6_9ACTN 
ID   K6VSL6_9ACTN            Unreviewed;       196 AA.
AC   K6VSL6;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   SubName: Full=Putative TetR family transcriptional regulator {ECO:0000313|EMBL:GAB89875.1};
GN   ORFNames=GORHZ_073_00180 {ECO:0000313|EMBL:GAB89875.1};
OS   Gordonia rhizosphera NBRC 16068.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC   Gordonia.
OX   NCBI_TaxID=1108045 {ECO:0000313|EMBL:GAB89875.1, ECO:0000313|Proteomes:UP000008363};
RN   [1] {ECO:0000313|EMBL:GAB89875.1, ECO:0000313|Proteomes:UP000008363}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 16068 {ECO:0000313|EMBL:GAB89875.1,
RC   ECO:0000313|Proteomes:UP000008363};
RA   Takarada H., Isaki S., Hosoyama A., Tsuchikane K., Katsumata H., Baba S.,
RA   Ohji S., Yamazaki S., Fujita N.;
RT   "Whole genome shotgun sequence of Gordonia rhizosphera NBRC 16068.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: TetR is the repressor of the tetracycline resistance element;
CC       its N-terminal region forms a helix-turn-helix structure and binds DNA.
CC       Binding of tetracycline to TetR reduces the repressor affinity for the
CC       tetracycline resistance gene (tetA) promoter operator sites.
CC       {ECO:0000256|ARBA:ARBA00002856}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAB89875.1}.
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DR   EMBL; BAHC01000073; GAB89875.1; -; Genomic_DNA.
DR   RefSeq; WP_006332278.1; NZ_BAHC01000073.1.
DR   AlphaFoldDB; K6VSL6; -.
DR   STRING; 1108045.GORHZ_073_00180; -.
DR   eggNOG; COG1309; Bacteria.
DR   OrthoDB; 3819648at2; -.
DR   Proteomes; UP000008363; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR004111; Repressor_TetR_C.
DR   InterPro; IPR003012; Tet_transcr_reg_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR   PANTHER; PTHR30055:SF151; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR   Pfam; PF02909; TetR_C_1; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   PRINTS; PR00400; TETREPRESSOR.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008363}.
FT   DOMAIN          2..62
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50977"
FT   DNA_BIND        25..44
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   196 AA;  20750 MW;  CEDCB911DE16BF62 CRC64;
     MSNTRADVLR AARDILTEHS LADLSMRRLA ADLGVRPNAL YWHFPNKQTL LAALSDEILS
     SVGAPPDALD WDDRLAHLAA GMRGALLDVP DSAEVVSSSW ASGLSPKTIA DEIADAARGG
     GLGERDASAV ATAICQLVIG LTIEEQTRAQ MERLQVTGPS GRDFTAEFTD GLNVILDGAR
     MRARRVTATG AMTDPG
//
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