ID K6Y8Y2_9ALTE Unreviewed; 799 AA.
AC K6Y8Y2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Arylsulfatase {ECO:0000313|EMBL:GAC13118.1};
DE EC=3.1.6.1 {ECO:0000313|EMBL:GAC13118.1};
GN Name=aslA {ECO:0000313|EMBL:GAC13118.1};
GN ORFNames=GLIP_0472 {ECO:0000313|EMBL:GAC13118.1};
OS Aliiglaciecola lipolytica E3.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Aliiglaciecola.
OX NCBI_TaxID=1127673 {ECO:0000313|EMBL:GAC13118.1, ECO:0000313|Proteomes:UP000006334};
RN [1] {ECO:0000313|EMBL:GAC13118.1, ECO:0000313|Proteomes:UP000006334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E3 {ECO:0000313|EMBL:GAC13118.1,
RC ECO:0000313|Proteomes:UP000006334};
RX PubMed=25009843;
RA Qin Q.-L., Xie B.-B., Yu Y., Shu Y.-L., Rong J.-C., Zhang Y.-J.,
RA Zhao D.-L., Chen X.-L., Zhang X.-Y., Chen B., Zhou B.-C., Zhang Y.-Z.;
RT "Comparative genomics of the marine bacterial genus Glaciecola reveals the
RT high degree of genomic diversity and genomic characteristic for cold
RT adaptation.";
RL Environ. Microbiol. 16:1642-1653(2014).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865}.
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAC13118.1}.
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DR EMBL; BAEN01000014; GAC13118.1; -; Genomic_DNA.
DR RefSeq; WP_008842938.1; NZ_BAEN01000014.1.
DR AlphaFoldDB; K6Y8Y2; -.
DR STRING; 1127673.GLIP_0472; -.
DR eggNOG; COG1621; Bacteria.
DR eggNOG; COG3119; Bacteria.
DR OrthoDB; 9803751at2; -.
DR Proteomes; UP000006334; Unassembled WGS sequence.
DR GO; GO:0004065; F:arylsulfatase activity; IEA:UniProtKB-EC.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd16144; ARS_like; 1.
DR Gene3D; 3.30.1120.10; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR42693:SF33; ARYLSULFATASE; 1.
DR PANTHER; PTHR42693; ARYLSULFATASE FAMILY MEMBER; 1.
DR Pfam; PF04616; Glyco_hydro_43; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS00523; SULFATASE_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:GAC13118.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006334};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..799
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003897226"
FT DOMAIN 31..379
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT SITE 649
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 799 AA; 88766 MW; 0356662BA9B36AD6 CRC64;
MKVLSIVAVM VLSICMLSAC NSTNSDKKKL NVLLILVDDL GWADVAAFNP NTNYSTPNMD
KLANQGLLFT DGYAASPVCS PTRASLLTGQ HPTRLSTTDF FRDQSRKHRY REGKFKPAQF
EEQLPTNIST IASVLGDDGY QTAFLGKWHL GQTEDGWPEH FGFDVNIGGH VAGAPRGGYF
SPYNNPRLES GPDGEYLTER LTSEAINLLE GYAQGESPFF MMMSYYSVHT PLDAPKETID
KYASKFAGTD PESEFVQVEQ IWPTDKPRLN RVKQTHATYA AMVEKVDENI GRLVDSLKAQ
NLAEDTIVIL LSDNGGLSTA EGLPTSNLPL RGGKGWLYEG GIRVPFVISV PGSKSMGTST
SVPATSTDIA ATLYDILGIN DNNIKQLDGD SLKAVINGES NVAERPLYFH YPHYSNQGGF
PGAAIRLGDW KLLERFEDGK VQLFNLAQDR EESNDLALEY PQRVAKMKEM LHRWYEDQDA
KFLRPNPTLP EYGQPWKPAQ DASQKIVISH SDLNGIGIEE NVMRRDPSDI IKVGDLYYVW
YSKGKVSTGY DATVWYATSE DGRHWTEKGE ALGKGTKGSW EGASVFTPNI LVAEGKYWLF
YTGTSKTYKQ PFSPDSKIGI VVSDSPDGPW QRFSNAPVLV NSENKDDFDS HLVDDSSLII
RDGKYWLYYK GRQLGKSPKH TQMGLAIAEN PEGPYIKVPN NPVIPGNHEV FVWPQGTGVA
AMIGERAPEE IQDSIMYAED GMNFIKTHEV INHPWAAGAY RPEAFTDSDL GEMPLWGVEI
GRAKKALPFI HRFDVTKEN
//
