ID K6YWH5_9ALTE Unreviewed; 718 AA.
AC K6YWH5;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=GTP pyrophosphokinase {ECO:0000256|ARBA:ARBA00019852};
DE EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
DE AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
DE AltName: Full=ppGpp synthase I {ECO:0000256|ARBA:ARBA00033308};
GN Name=relA {ECO:0000313|EMBL:GAC15605.1};
GN ORFNames=GLIP_2984 {ECO:0000313|EMBL:GAC15605.1};
OS Aliiglaciecola lipolytica E3.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Aliiglaciecola.
OX NCBI_TaxID=1127673 {ECO:0000313|EMBL:GAC15605.1, ECO:0000313|Proteomes:UP000006334};
RN [1] {ECO:0000313|EMBL:GAC15605.1, ECO:0000313|Proteomes:UP000006334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E3 {ECO:0000313|EMBL:GAC15605.1,
RC ECO:0000313|Proteomes:UP000006334};
RX PubMed=25009843;
RA Qin Q.-L., Xie B.-B., Yu Y., Shu Y.-L., Rong J.-C., Zhang Y.-J.,
RA Zhao D.-L., Chen X.-L., Zhang X.-Y., Chen B., Zhou B.-C., Zhang Y.-Z.;
RT "Comparative genomics of the marine bacterial genus Glaciecola reveals the
RT high degree of genomic diversity and genomic characteristic for cold
RT adaptation.";
RL Environ. Microbiol. 16:1642-1653(2014).
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004976}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAC15605.1}.
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DR EMBL; BAEN01000059; GAC15605.1; -; Genomic_DNA.
DR RefSeq; WP_008845410.1; NZ_BAEN01000059.1.
DR AlphaFoldDB; K6YWH5; -.
DR STRING; 1127673.GLIP_2984; -.
DR eggNOG; COG0317; Bacteria.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000006334; Unassembled WGS sequence.
DR GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF40; GTP PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:GAC15605.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006334};
KW Transferase {ECO:0000313|EMBL:GAC15605.1}.
FT DOMAIN 388..449
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 643..718
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT REGION 550..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 718 AA; 82044 MW; 555CB0DD1837BD95 CRC64;
MVSIRTVHQP ERPNFDQWLD CLNLPQSTKQ KLRDTSESPE ILLVGQEMVE ILHELNMDDE
TLQASLVYPY CELHGLDDEQ IEEEFGKGIR NLISGVRRMD AIKTLHSRSN KKADEVQIDN
IRRMLLAMVE DVRTVLIKLA ERICTLQKMK KADEETRVIV ARECSTIYAP LANRLGIGQL
KWEIEDLSFR YLHPEKYKQI ASLLDEKRTD RQQYIEDFVT NLQAEMDEAK INVKVYGRPK
HIYSIWKKMQ KKHLSFDQLY DIRAVRIIAD RLQDCYSALG IVHSLFKHIP NEFDDYIATP
KPNGYQSIHT VVVGPQGRSV EIQIRTQQMH QDAELGIAAH WKYKEGVSSE RSAYEDKINW
LRKILLWQEE VAESGDLVEE LRSQVFDDRV YVFTPKGDVI DLPLGSTPLD FAYYIHSNVG
HRCNGAKVNG RIVTFTYQLQ TGDQVEVLTG KNLNPSRDWM HPGLGYVHSS RARAKIHTWF
KKQDKEKNLQ AGKELLEREL SRANLVLKDA AKACERFNVN QVDDLYAAIG GGDLRIMQVV
NYLQQLDAPP PEIDPRVRTT QSKPTKGGKS TIVVEGVGNL MSQIAKCCQP LPGDPIQGYI
TMGRGVSVHR ENCDQLNHLL DQHPEREIEV NWANDLRGSF KTDLDVHTSD RDGILRDITT
VLANDKITLL GVNSLSNTKD QTARIRITLE LKDLASLSKT TARLLQIKGV IDVVRLDK
//
