ID K6Z6W2_PHLPR Unreviewed; 229 AA.
AC K6Z6W2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=GTP-binding nuclear protein {ECO:0000256|RuleBase:RU363057};
DE Flags: Fragment;
OS Phleum pratense (Common timothy).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Poodae; Poeae; Poeae Chloroplast Group 2 (Poeae type); Poodinae;
OC Phleinae; Phleum.
OX NCBI_TaxID=15957 {ECO:0000313|EMBL:JAA00126.1};
RN [1] {ECO:0000313|EMBL:JAA00126.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pollen {ECO:0000313|EMBL:JAA00126.1};
RX PubMed=23401558; DOI=10.1073/pnas.1300512110;
RA Schulten V., Greenbaum J.A., Hauser M., McKinney D.M., Sidney J., Kolla R.,
RA Lindestam Arlehamn C.S., Oseroff C., Alam R., Broide D.H.,
RA Ferreira-Briza F., Grey H.M., Sette A., Peters B.;
RT "Previously undescribed grass pollen antigens are the major inducers of T
RT helper 2 cytokine-producing T cells in allergic individuals.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:3459-3464(2013).
CC -!- FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport.
CC Required for the import of protein into the nucleus and also for RNA
CC export. Involved in chromatin condensation and control of cell cycle.
CC {ECO:0000256|ARBA:ARBA00024659, ECO:0000256|RuleBase:RU363057}.
CC -!- SUBUNIT: Found in a nuclear export complex with RanGTP, exportin and
CC pre-miRNA. {ECO:0000256|ARBA:ARBA00026078}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU363057}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ran family.
CC {ECO:0000256|ARBA:ARBA00008028, ECO:0000256|RuleBase:RU363057}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GAAJ01000338; JAA00126.1; -; mRNA.
DR AlphaFoldDB; K6Z6W2; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00877; Ran; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002041; Ran_GTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR24071:SF44; GTP-BINDING NUCLEAR PROTEIN RAN-2; 1.
DR PANTHER; PTHR24071; RAN GTPASE; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00627; GTPRANTC4.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00176; RAN; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51418; RAN; 1.
DR PROSITE; PS51421; RAS; 1.
PE 2: Evidence at transcript level;
KW GTP-binding {ECO:0000256|RuleBase:RU363057};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363057};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU363057};
KW Protein transport {ECO:0000256|RuleBase:RU363057};
KW Transport {ECO:0000256|RuleBase:RU363057}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:JAA00126.1"
SQ SEQUENCE 229 AA; 25796 MW; 6C2F136575BE2D3C CRC64;
PSPPALVPMA LPNQGTVDYP SFKLVIVGDG GTGKTTFVKR HLTGEFEKKY EPTIGVEVHP
LDFTTNCGKI RFYCWDTAGQ EKFGGLRDGY YIHGQCAIIM FDVTSRLTYK NVPTWHRDLC
RVCENIPIVL CGNKVDVKNR QVKAKQVTFH RKKNLQYYEI SAKSNYNFEK PFLYLARKLA
GDANIHFVEA VALKPPEVTF DLAMQQQHEA ELAAAAAQPL PDDDDDLVE
//
