ID K7A680_PANTR Unreviewed; 1176 AA.
AC K7A680; A0A2J8NY32;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE SubName: Full=Euchromatic histone-lysine N-methyltransferase 2 {ECO:0000313|EMBL:JAA13211.1};
GN Name=EHMT2 {ECO:0000313|EMBL:JAA13211.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA13211.1};
RN [1] {ECO:0000313|EMBL:JAA13211.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skin {ECO:0000313|EMBL:JAA27181.1}, and Smooth vascular
RC {ECO:0000313|EMBL:JAA13211.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GABF01008934; JAA13211.1; -; mRNA.
DR EMBL; GABD01005919; JAA27181.1; -; mRNA.
DR RefSeq; XP_016810696.1; XM_016955207.1.
DR AlphaFoldDB; K7A680; -.
DR GeneID; 462572; -.
DR CTD; 10919; -.
DR OrthoDB; 5481936at2759; -.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd20905; EHMT_ZBD; 1.
DR CDD; cd10533; SET_EHMT2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR043550; EHMT1/EHMT2.
DR InterPro; IPR047762; EHMT_CRR.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR038034; SET_EHMT2.
DR PANTHER; PTHR46307; G9A, ISOFORM B; 1.
DR PANTHER; PTHR46307:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF21533; EHMT1-2_CRR; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Methyltransferase {ECO:0000313|EMBL:JAA13211.1};
KW Transferase {ECO:0000313|EMBL:JAA13211.1}.
FT REPEAT 650..682
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 683..715
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 716..740
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 750..782
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 816..848
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 938..1001
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 1004..1121
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..328
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..365
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1176 AA; 128979 MW; 7D11B3C7C83B0E67 CRC64;
MAAAAGAAAA AAAEGEAPAE MGALLLEKET RGATERAHGS LGDTPRSEET LPKATPDSLE
PAGPSSPASV TVTVGDEGAD TPVGATPLIG DESENLEGDG DLRGGRILLG HATKSFPSSP
SKGGSCPSRA KMSMTGAGKS PPSVQSLAMR LLSMPGAQGA AAAGSEPPPA TTSPEGQPKV
HRARKTMSKP GNGQPPVPEK RPPEVQHFRM SDDVHSLGKV TSDLAKRRKL NSGGGLSEEL
GSARRSGEVT LTKGDPGSLE EWETVVGDDF SLYYDSYSVD ERVDSDSKSE VEALTEQLSE
EEEEEEEEEE EEEEEEEEEE EEEDEESGNQ SDRSGSSGRR KAKKKWRKDS PWVKPSRKRR
KREPPRAKEP RGVSNDTSSL ETERGFEELP LCSCRMEAPK IDRISERAGH KCMATESVDG
ELSGCNAAIL KRETMRPSSR VALMVLCETH RARMVKHHCC PGCGYFCTAG TFLECHPDFR
VAHRFHKACV SQLNGMVFCP HCGEDASEAQ EVTIPRGDGV TPPAGTAAPA PPPLSQDAPG
RADTSQPSAR MRGHGEPRRP PCDPLADTID SSGPSLTLPN GGCLSAVGLP LGPGREALEK
ALVIQESERR KKLRFHPRQL YLSVKQGELQ KVILMLLDNL DPNFQSDQQS KRTPLHAAAQ
KGSVEICHVL LQAGANINAV DKQQRTPLME AVVNNHLEVA RYMVQRGGCV YSKEEDGSTC
LHHAAKIGNL EMVSLLLSTG QVDVNAQDSG GWTPIIWAAE HKHIEVIRML LTRGADVTLT
DNEENICLHW ASFTGSAAIA EVLLNARCDL HAVNYHGDTP LHIAARESYH DCVLLFLSRG
ANPELRNKEG DTAWDLTPER SDVWFALQLN RKLRLGVGNR AIRTEKIICR DVARGYENVP
IPCVNGVDGE PCPEDYKYIS ENCETSTMNI DRNITHLQHC TCVDDCSSSN CLCGQLSIRC
WYDKDGRLLQ EFNKIEPPLI FECNQACSCW RNCKNRVVQS GIKVRLQLYR TAKMGWGVRA
LQTIPQGTFI CEYVGELISD AEADVREDDS YLFDLDNKDG EVYCIDARYY GNISRFINHL
CDPNIIPVRV FMLHQDLRFP RIAFFSSRDI RTGEELGFDY GDRFWDIKSK YFTCQCGSEK
CKHSAEAIAL EQSRLARLDP HPELLPELSS LPPVNT
//
