ID K7AG48_PANTR Unreviewed; 1662 AA.
AC K7AG48; A0A2J8LG43;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Scribbled homolog {ECO:0000313|EMBL:JAA16936.1};
GN Name=SCRIB {ECO:0000313|EMBL:JAA16936.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA16936.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000093223.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA16936.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Smooth vascular {ECO:0000313|EMBL:JAA16936.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000093223.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the LAP (LRR and PDZ) protein family.
CC {ECO:0000256|ARBA:ARBA00007772}.
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DR EMBL; AC195637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABF01005209; JAA16936.1; -; mRNA.
DR STRING; 9598.ENSPTRP00000093223; -.
DR Ensembl; ENSPTRT00000084278.1; ENSPTRP00000093223.1; ENSPTRG00000020669.5.
DR GeneTree; ENSGT00940000154025; -.
DR Proteomes; UP000002277; Chromosome 8.
DR Bgee; ENSPTRG00000020669; Expressed in hindlimb stylopod muscle and 21 other cell types or tissues.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR GO; GO:0098968; P:neurotransmitter receptor transport postsynaptic membrane to endosome; IBA:GO_Central.
DR GO; GO:0098887; P:neurotransmitter receptor transport, endosome to postsynaptic membrane; IBA:GO_Central.
DR GO; GO:0043113; P:receptor clustering; IBA:GO_Central.
DR CDD; cd00992; PDZ_signaling; 4.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF44; PROTEIN SCRIBBLE HOMOLOG; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF00595; PDZ; 4.
DR SMART; SM00364; LRR_BAC; 10.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00228; PDZ; 4.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50106; PDZ; 4.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 730..817
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 864..952
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1011..1100
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1107..1195
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 417..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 951..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1287..1498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1526..1576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1597..1662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..492
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..587
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..694
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..987
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1340..1354
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1387..1409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1446..1463
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1662 AA; 178539 MW; 7303E06E7CCE583F CRC64;
MLKCIPLWRC NRHVESVDKR HCSLQAVPEE IYRYSRSLEE LLLDANQLRE LPKPFFRLLN
LRKLGLSDNE IQRLPPEVAN FMQLVELDVS RNDIPEIPES IKFCKALEIA DFSGNPLSRL
PDGFTQLRSL AHLALNDVSL QALPGDVGNL ANLVTLELRE NLLKSLPASL SFLVKLEQLD
LGGNDLEVLP DTLGALPNLR ELWLDRNQLS ALPPELGNLR RLVCLDVSEN RLEELPAELG
GLVLLTDLLL SQNLLRRLPD GIGQLKQLSI LKVDQNRLCE VTEAIGDCEN LSELILTENL
LMALPRSLGK LTKLTNLNVD RNHLEALPPE IGGCVALSVL SLRDNRLAVL PPELAHTAEL
HVLDVAGNRL QSLPFALTHL NLKALWLAEN QAQPMLRFQT EDDARTGEKV LTCYLLPQQP
PPSLEDAGQQ GSLSETWSDA PPSRVSVIQF LEAPIGDEDA EEAAAEKRGL QRRATPHPSE
LKVMKRSIEG RRSDACPCQP DSGSPLSAEE EKRLSAESGL SEDSRPSAST VSEAEPEGPS
AEAQGGSQQE ATTAGGEDTE EDYQEPTVHF AEDALLPGDD REIEEGQPEA PWTLPGGRQR
LIRKDTPHYK KHFKISKLPQ PEAVVALLQG MQPDGEGPVA PGGWHNGPHA PWAPQAQKEE
EEEEEEEGSP REEEEEEEEE ENRAEEEEAS TEEEDKEGAV VSAPSVKGVS FDQANNLLIE
PARIEEEELT LTILRQTGGL GISIAGGKGS TPYKGDDEGI FISRVSEEGP AARAGVRVGD
KLLEVNGVAL QGAEHHEAVE ALRGAGTAVQ MRVWRERMVE PENAVTITPL RPEDDYSPRE
RRGGGLRLPL LPPESPGPLR QRHVACLARS ERGLGFSIAG GKGSTPYRAG DAGIFVSRIA
EGGAAHRAGT LQVGDRVLSI NGVDVTEARH DHAVSLLTAA SPTIALLLER EAGGPLPPSP
LPHSSPPTAA VATTSTTTTS ITTATPGEPG LPSLAPSLLA AALEGPYPVE EIRLPRAGGP
LGLSIVGGSD HSSHPFGVQE PGVFISKVLP RGLAARSGLR VGDRILAVNG QDVRDATHQE
AVSALLRPCL ELSLLVRRDP APPGLRELCI QKAPGERLGI SIRGGARGHA GNPRDPTDEG
IFISKVSPTG AAGRDGRLRV GLRLLEVNQQ SLLGLTHGEA VQLLRSVGDT LTVLVCDGFE
ASTAAALEVS PGVIANPFAA GIGHRNSLES ISSIDRELSP EGPGKEKELP GQTLHWGPEA
TEAAGRGLQP LKLDYRALAA VPSAGSVQRV PSGAAGGKMA ECPCFPSGQQ PPSPPSPDEL
PANVKQAYRA FAAVPTSHPP EDAPAQPPTP GPAASPEQLS FRERQKYFEL EVRVPQAEGP
PKRVSLVGAD DLRKMQEEEA RKLQQKRAQM LREAAEAGAE ARLALDGETL GEEEQEDEQP
PWASPSPTSR QSPASPPPPG GGAPVRTAKA ERRHQERLRV QSPEPPAPER ALSPAERRAL
EAEKRALWRA ARMKSLEQDA LRAQMVLSRS QEGRGTRGPL ERLAEAPSPA PTPSPTPVED
LGPQTSTSPG RLPLSGKKFD YRAFAALPSS RPVYDIQSPD FAEELRSLEP SPSPGPQEED
GEVALVLLGR PSPGAVGPED VALCSSRRPV RPGRRGLGPV PS
//
