ID K7AKK8_PHLPR Unreviewed; 424 AA.
AC K7AKK8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 03-MAY-2023, entry version 20.
DE RecName: Full=phospholipase D {ECO:0000256|ARBA:ARBA00012027};
DE EC=3.1.4.4 {ECO:0000256|ARBA:ARBA00012027};
DE Flags: Fragment;
OS Phleum pratense (Common timothy).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Poodae; Poeae; Poeae Chloroplast Group 2 (Poeae type); Poodinae;
OC Phleinae; Phleum.
OX NCBI_TaxID=15957 {ECO:0000313|EMBL:JAA00300.1};
RN [1] {ECO:0000313|EMBL:JAA00300.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pollen {ECO:0000313|EMBL:JAA00300.1};
RX PubMed=23401558; DOI=10.1073/pnas.1300512110;
RA Schulten V., Greenbaum J.A., Hauser M., McKinney D.M., Sidney J., Kolla R.,
RA Lindestam Arlehamn C.S., Oseroff C., Alam R., Broide D.H.,
RA Ferreira-Briza F., Grey H.M., Sette A., Peters B.;
RT "Previously undescribed grass pollen antigens are the major inducers of T
RT helper 2 cytokine-producing T cells in allergic individuals.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:3459-3464(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:14445,
CC ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58608; EC=3.1.4.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000798};
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DR EMBL; GAAJ01000164; JAA00300.1; -; mRNA.
DR AlphaFoldDB; K7AKK8; -.
DR GO; GO:0070290; F:N-acylphosphatidylethanolamine-specific phospholipase D activity; IEA:UniProtKB-EC.
DR GO; GO:0004630; F:phospholipase D activity; IEA:UniProtKB-EC.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR InterPro; IPR024632; PLipase_D_C.
DR InterPro; IPR015679; PLipase_D_fam.
DR PANTHER; PTHR18896; PHOSPHOLIPASE D; 1.
DR PANTHER; PTHR18896:SF67; PHOSPHOLIPASE D; 1.
DR Pfam; PF12357; PLD_C; 1.
DR Pfam; PF00614; PLDc; 1.
DR SMART; SM00155; PLDc; 1.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 1.
PE 2: Evidence at transcript level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022963}.
FT DOMAIN 270..297
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:JAA00300.1"
SQ SEQUENCE 424 AA; 47741 MW; 06B534B8C7B980F2 CRC64;
HQPNFATAAI TKGGPREPWH DIHCRLEGPV AWDVLYNFEQ RWRKQGGKDL LIQLRDLADE
IIPPSPVVYA EDREAWNVQL FRSIDGGAAF GFPDTPEDAA RAGLVSGKDQ IIDRSIQDAY
ICAIRRAKSF IYIENQYFLG SSYCWKPDGI KPDDVGALHL IPKELSMKVV SKIEAGERFT
VYVVVPMWPE GIPASGSVQA ILDWQRRTME MMYTDIAQAI QAKGIDANPK DYLTFFCLGN
REAKKAGEYE PPEPAEPDSD YLKAQQNRRF MIYVHTKMMI VDDEYIIVGS ANINQRSMDG
ARDSEIAMGA YQPYHLAASR PARGQVHGFR MALWYEHLGM VDEAFQRPES VECVRKVNAM
ADRYWNLYAG DGPERDLPGH LLTYPVGVTS DGTVTQLPGV EFFPDTQARI LGAKSDYLPP
ILTT
//
