ID K7B1J6_PANTR Unreviewed; 228 AA.
AC K7B1J6; H2RFP4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Fibronectin type III domain containing 5 {ECO:0000313|EMBL:JAA00532.1, ECO:0000313|Ensembl:ENSPTRP00000060338.2};
GN Name=FNDC5 {ECO:0000313|EMBL:JAA00532.1,
GN ECO:0000313|Ensembl:ENSPTRP00000060338.2,
GN ECO:0000313|VGNC:VGNC:10645};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA00532.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000060338.2, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA00532.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA00532.1}, and Skin
RC {ECO:0000313|EMBL:JAA22644.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000060338.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AACZ04072178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01010806; JAA00532.1; -; mRNA.
DR EMBL; GABD01010456; JAA22644.1; -; mRNA.
DR RefSeq; XP_001155446.4; XM_001155446.4.
DR Ensembl; ENSPTRT00000073759.2; ENSPTRP00000060338.2; ENSPTRG00000000493.6.
DR GeneID; 746970; -.
DR KEGG; ptr:746970; -.
DR CTD; 252995; -.
DR VGNC; VGNC:10645; FNDC5.
DR GeneTree; ENSGT00390000004923; -.
DR OrthoDB; 5350070at2759; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000000493; Expressed in skeletal muscle tissue and 16 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0090336; P:positive regulation of brown fat cell differentiation; IBA:GO_Central.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR14470; FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR14470:SF1; FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 5; 1.
DR Pfam; PF00041; fn3; 1.
DR SMART; SM00060; FN3; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50853; FN3; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..228
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014305816"
FT TRANSMEM 155..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..127
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 183..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 228 AA; 25455 MW; 6CF976FBC1E621B3 CRC64;
MHPGSPSAWP PRARAALRLW LGCVCFALVQ ADSPSAPVNV TVRHLKANSA VVSWDVLEDE
VVIGFAISQQ KKDVRMLRFI QEVNTTTRSC ALWDLEEDTE YIVHVQAISI QGQSPASEPV
LFKTPREAEK MASKNKDEVT MKEMGRNQQL RTGEVLIIVV VLFMWAGVIA LFCRQYDIIK
DNEPNNNKEK TKSASETSTP EHQGGGLLRS KVRARPGPGW ATLCLMLW
//