ID K7BBK2_PANTR Unreviewed; 675 AA.
AC K7BBK2; A0A2J8N9W7; H2R624;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=G-protein-signaling modulator 1 {ECO:0000313|EMBL:JAA04027.1, ECO:0000313|Ensembl:ENSPTRP00000048673.3};
GN Name=GPSM1 {ECO:0000313|EMBL:JAA04027.1,
GN ECO:0000313|Ensembl:ENSPTRP00000048673.3, ECO:0000313|VGNC:VGNC:8891};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA04027.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000048673.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA04027.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA04027.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA43736.1}, Skin {ECO:0000313|EMBL:JAA31082.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA18501.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000048673.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GPSM family.
CC {ECO:0000256|ARBA:ARBA00006600}.
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DR EMBL; AACZ04057940; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01007311; JAA04027.1; -; mRNA.
DR EMBL; GABF01003644; JAA18501.1; -; mRNA.
DR EMBL; GABD01002018; JAA31082.1; -; mRNA.
DR EMBL; GABE01001003; JAA43736.1; -; mRNA.
DR RefSeq; XP_016817593.1; XM_016962104.1.
DR STRING; 9598.ENSPTRP00000072267; -.
DR PaxDb; 9598-ENSPTRP00000048673; -.
DR Ensembl; ENSPTRT00000049215.4; ENSPTRP00000048673.3; ENSPTRG00000021549.6.
DR GeneID; 464915; -.
DR CTD; 26086; -.
DR VGNC; VGNC:8891; GPSM1.
DR eggNOG; KOG1130; Eukaryota.
DR GeneTree; ENSGT00940000154667; -.
DR OMA; HANIANC; -.
DR OrthoDB; 4190321at2759; -.
DR TreeFam; TF328344; -.
DR Proteomes; UP000002277; Chromosome 9.
DR Bgee; ENSPTRG00000021549; Expressed in cerebellar cortex and 20 other cell types or tissues.
DR GO; GO:0030695; F:GTPase regulator activity; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR45954:SF2; G-PROTEIN-SIGNALING MODULATOR 1; 1.
DR PANTHER; PTHR45954; LD33695P; 1.
DR Pfam; PF02188; GoLoco; 4.
DR Pfam; PF13424; TPR_12; 3.
DR SMART; SM00390; GoLoco; 4.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50877; GOLOCO; 4.
DR PROSITE; PS50005; TPR; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 249..282
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 391..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 644..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..440
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 675 AA; 74521 MW; 4C8DF1EE4712C2D4 CRC64;
MAGPAPPAAD ELPGPAARRL YSRMEASCLE LALEGERLCK AGDFKAGVAF FEAAVQVGTE
DLKTLSAIYS QLGNAYFYLK EHGRALEYHK HDLLLARTIG DRMGEAKASG NLGNTLKVLG
RFDEAAVCCQ RHLSIAQEQG DKVGEARALY NIGNVYHAKG KQLSWNTAHA TQDPGHLPPD
VRETLCKASE FYERNLSLVK ELGDRAAQGR AYGNLGNTHY LLGNFTEATT FHKERLAIAK
EFGDKAAERR AYSNLGNAHV FLGRFDVAAE YYKKTLQLSR QLRDQAVEAQ ACYSLGNTYT
LLQDYERAAE YHLRHLLIAQ ELADRVGEGR ACWSLGNAYV SMGRPAQALT FAKKHLQISQ
EIGDRHGELT ARMNVAQLQL VLGRLTSPAA SEKPDLAGYE AQGARPKRTQ RLSAETWDLL
RLPLEREQNG DSHHSGDWRG PSRDSLPLLV RSRKYQEGPD AERRPREGSH SPLDSADVRV
HVPRTSIPRA PSSDEECFFD LLTKFQSSRM DDQRCPLDDG QAGAAEATAA PTLEDRIAQP
SMTASPQTEE FFDLIASSQS RRLDDQRASV GSLPGLRITH SNAGHLRGHG EPQEPGDDFF
NMLIKYQSSR IDDQRCPPPD VLPRGPTMPD EDFFSLIQRV QAKRMDEQRV DLAGGPEQGA
GGPPEPQQQC QPGAS
//
