ID K7BFD5_PANTR Unreviewed; 162 AA.
AC K7BFD5; A0A2J8IL04;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Sorting nexin 12 {ECO:0000313|EMBL:JAA18908.1, ECO:0000313|Ensembl:ENSPTRP00000089547.1};
GN Name=SNX12 {ECO:0000313|EMBL:JAA18908.1,
GN ECO:0000313|Ensembl:ENSPTRP00000089547.1,
GN ECO:0000313|VGNC:VGNC:11635};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA18908.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000089547.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA18908.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA03477.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA34044.1}, Skin {ECO:0000313|EMBL:JAA24947.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA18908.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000089547.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; AACZ04024675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04024676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01007861; JAA03477.1; -; mRNA.
DR EMBL; GABF01003237; JAA18908.1; -; mRNA.
DR EMBL; GABD01008153; JAA24947.1; -; mRNA.
DR EMBL; GABE01010695; JAA34044.1; -; mRNA.
DR RefSeq; XP_016799180.1; XM_016943691.1.
DR Ensembl; ENSPTRT00000080048.1; ENSPTRP00000089547.1; ENSPTRG00000022003.5.
DR GeneID; 473658; -.
DR KEGG; ptr:473658; -.
DR CTD; 29934; -.
DR VGNC; VGNC:11635; SNX12.
DR GeneTree; ENSGT00940000153609; -.
DR OMA; GWSRVWQ; -.
DR OrthoDB; 5475877at2759; -.
DR Proteomes; UP000002277; Chromosome X.
DR Bgee; ENSPTRG00000022003; Expressed in Brodmann (1909) area 10 and 21 other cell types or tissues.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd07294; PX_SNX12; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR PANTHER; PTHR45963; RE52028P; 1.
DR PANTHER; PTHR45963:SF2; SORTING NEXIN-12; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 2: Evidence at transcript level;
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 28..152
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 162 AA; 18885 MW; 48CBC16A86AFDB08 CRC64;
MSDTAVADTR RLNSKPQDLT DAYGPPSNFL EIDIFNPQTV GVGRARFTTY EVRMRTNLPI
FKLKESCVRR RYSDFEWLKN ELERDSKIVV PPLPGKALKR QLPFRGDEGI FEESFIEERR
QGLEQFINKI AGHPLAQNER CLHMFLQEEA IDRNYVPGKV RQ
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