ID   K7BR26_PANTR            Unreviewed;       879 AA.
AC   K7BR26;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN   Name=OSBPL5 {ECO:0000313|EMBL:JAA09117.1};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA09117.1};
RN   [1] {ECO:0000313|EMBL:JAA09117.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA09117.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT   mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
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DR   EMBL; GABC01002221; JAA09117.1; -; mRNA.
DR   AlphaFoldDB; K7BR26; -.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd13286; PH_OPR5_ORP8; 1.
DR   Gene3D; 1.10.287.2720; -; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF221; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 5; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          126..243
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          254..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          742..805
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          96..123
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        299..326
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        327..342
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        766..786
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   879 AA;  98651 MW;  A42CCC1CF25C0694 CRC64;
     MKEEAFLRRR FSLCPPSSTP QKVDPRKLTR NLLLGGDNEL YPLSPGKDLE PNGPSLPRDE
     GPPTPSSATK VPLAEYRLCN GSDKECVSPT ARVTKKETLK AQKENYRQEK KRATRQLLSA
     LTDPSVVIMA DSLKIRSTLK SWTKLWCVLK PGVLLIYKTP KVGQWVGTVL LHCCELIERP
     SKKDGFCFKL FHPLDQSVWA VKGPKGESVG SITQPLPSSY LIFRAASESD GRCWLDALEL
     ALRCSSLLRL GTCKPGRDGE PGTSPDTSPS SLCGLPASAT VHPDQDLFPL NGSSLENDAF
     SDKSERENPE ESDTETQDHS RKTESGSDQS ETPGASARRG TTYVEQVQED LGELGEASQV
     ETVSEENKSL MWTLLKQLRP GMDLSRVVLP TFVLEPRSFL NKLSDYYYHA DLLSRAAVEE
     DAYSRMKLVL RWYLSGFYKK PKGIKKPYNP ILGETFRCCW FHPQTDSRTF YIAEQVSHHP
     PVSAFHVSNR KDGFCISGSI TAKSRFYGNS LSALLDGKAT LTFLNRAEDY TLTMPYAHCK
     GILYGTMTLE LGGKVTIECA KNNFQAQLEF KLKPFFGGST SINQISGKIT SGEEVLASLS
     GHWDRDVFIK EEGSGSSALF WTPSGEVRRQ RLRQHTVPLE EQMELESERL WQHVTRAISK
     GDQHRATQEK FALEEAQRRR ARERQESLMP WKPQLFHLDP ITQEWHYRYE DHSPWDPLKD
     IAQFEQDGIL RTLQQEAVAR QTTFLGSPGP RHERSGPDQR LRKASDQPSG HSQATESSGS
     TPESCPELSD EEQDGDFVPG GESPCPRCRK EARRLQVLHE AILSIQEAQQ ELHRHLSAML
     SSTARAAQAP TPGLLQSPRS WFLLCVFLAC QLFINHILK
//