ID K7C450_PANTR Unreviewed; 1196 AA.
AC K7C450; A0A2J8PSU1; H2QTS6;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Abelson helper integration site 1 {ECO:0000313|EMBL:JAA37336.1, ECO:0000313|Ensembl:ENSPTRP00000031804.5};
GN Name=AHI1 {ECO:0000313|EMBL:JAA37336.1,
GN ECO:0000313|Ensembl:ENSPTRP00000031804.5, ECO:0000313|VGNC:VGNC:2665};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA37336.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000031804.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA37336.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA04418.1}, and Skeletal
RC muscle {ECO:0000313|EMBL:JAA37336.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000031804.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04054439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01006920; JAA04418.1; -; mRNA.
DR EMBL; GABC01006919; JAA04419.1; -; mRNA.
DR EMBL; GABE01007404; JAA37335.1; -; mRNA.
DR EMBL; GABE01007403; JAA37336.1; -; mRNA.
DR RefSeq; XP_001170641.1; XM_001170641.4.
DR RefSeq; XP_527511.3; XM_527511.5.
DR STRING; 9598.ENSPTRP00000031804; -.
DR PaxDb; 9598-ENSPTRP00000031804; -.
DR Ensembl; ENSPTRT00000034408.5; ENSPTRP00000031804.5; ENSPTRG00000018632.6.
DR GeneID; 472132; -.
DR CTD; 54806; -.
DR VGNC; VGNC:2665; AHI1.
DR eggNOG; KOG0266; Eukaryota.
DR GeneTree; ENSGT00940000156509; -.
DR OMA; IMTQPCD; -.
DR OrthoDB; 49443at2759; -.
DR TreeFam; TF329226; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000018632; Expressed in pituitary gland and 21 other cell types or tissues.
DR GO; GO:0005912; C:adherens junction; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0044458; P:motile cilium assembly; IBA:GO_Central.
DR CDD; cd11812; SH3_AHI-1; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR035832; AHI1_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44499; JOUBERIN; 1.
DR PANTHER; PTHR44499:SF1; JOUBERIN; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 650..682
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 693..735
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 740..772
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 851..880
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1051..1111
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 31..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1115..1196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..326
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1196 AA; 137245 MW; E64D86BEFADA6540 CRC64;
MPTAESEAKV KTKVRFEELL KTHSDLMHEK KKLKKKLVKS EENISPDTIR SNLHYMKETT
SDDPDTIRSN LPHIKETTSD DVSAANTNNL KKSMRVTKNK LRNTQSATEN PNGDASVEED
KQGKPNKKVI KMVPQLTTQD LKPETPEKKV DSTHQKTHTK PQPGVDHQKS EKANEGREEN
DLEEDEELMQ AYQCHVTEEM AKEIKKKIRK KLKEQLTYFP SDTLFHDDKL SSEKRKKKKE
VPVFSKAETS TLTISGDTVE GEQKKESSVR SVSSDSHQDD EISSMEQSTE DSMQDDTKPK
PKKTKKKTKA VADNNEDVDG DGVHEITSRD SPVYPKCLLD DDLVLGVYIH RTDRLKSDFM
ISHPMVKIHV VDEHTGQYVK KDDSERPVSS YYEKENVDYI LPIMTQPYDF KQLKSRLPEW
EEQIVFNENF PYLLRGSDES PKVILFFEIL DFLSMDEIKN NSEVQNQECG FRKIAWAFLK
LLGANGNANI NSKLRLQLYY PPTKPRSQLN VVEAFEWWSK CPRNHYPSTL YVTVRGLKVP
DRIKPSYRSM MALQEEKGKP VHCERHHESS SVDTEPGLEE SKEVIKWKRL PGQACRIPNK
HLFSLNAGER GCFCLDFSHN GRILAAACAS RDGYPIILYE IPSGRFMREL CGHLNIIYDL
SWSKDDHYIL TSSSDGTARI WKNEINNTNA FKVLPHPSFV YTAKFHPAVR ELVVTGCYDS
MIRIWKVEMR EDSAILVRQF DVHKSFINSL CFDTEGHHMY SGDCTGVIVV WNTYVKVNDL
EHSVRHWTIN KEIKETEFKG IPISYLEIHP NGKRLLIHTK DSTLRIMDLR ILVARKFVGA
ANYREKIHST LTPCGTFLFA GSEDGIVYVW NPETGEQVAM YSDLPFKSPI RDISYHPFEN
MVAFCAFGQN EPILLYIYDF HVAQQEAEMF KRYNGTFPLP GIHQSQDALC TCPKLPHQGS
FQIDEFVHTE SSSTKMQLVK QRLETVTEVI RSCAAKVNKN LSFTSPPAVS SQQSKLKQSN
ILTAQEILHQ FGFTQTGIIS IERKPCNHQV DTAPTVVALY DYTANRSDEL TIHRGDIIRV
FFKDNEDWWY GSIGKGQEGY FPANHVASET LYQELPPEIK ERSPPLSPEE KTKIEKSPAP
QKQSINKNKS QDFRLGSESM THSEMRKEQS HEDQGHIMDT RMRKNKQAGR KVTLIE
//
