ID K7CQC4_PANTR Unreviewed; 1070 AA.
AC K7CQC4; A0A2J8MNQ9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=MLLT10 histone lysine methyltransferase DOT1L cofactor {ECO:0000313|Ensembl:ENSPTRP00000078045.1};
DE SubName: Full=Myeloid/lymphoid or mixed-lineage leukemia translocated to, 10 {ECO:0000313|EMBL:JAA21167.1};
GN Name=MLLT10 {ECO:0000313|EMBL:JAA21167.1,
GN ECO:0000313|Ensembl:ENSPTRP00000078045.1,
GN ECO:0000313|VGNC:VGNC:14870};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA21167.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000078045.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA21167.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA09742.1}, Skin
RC {ECO:0000313|EMBL:JAA29835.1}, and Smooth vascular
RC {ECO:0000313|EMBL:JAA21167.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000078045.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04070773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04070774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04070775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04070776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01001596; JAA09742.1; -; mRNA.
DR EMBL; GABF01000978; JAA21167.1; -; mRNA.
DR EMBL; GABD01003265; JAA29835.1; -; mRNA.
DR RefSeq; XP_016818236.1; XM_016962747.1.
DR STRING; 9598.ENSPTRP00000078045; -.
DR Ensembl; ENSPTRT00000095165.1; ENSPTRP00000078045.1; ENSPTRG00000002346.7.
DR GeneID; 450343; -.
DR CTD; 8028; -.
DR VGNC; VGNC:14870; MLLT10.
DR GeneTree; ENSGT00940000157711; -.
DR OMA; XFSELLN; -.
DR OrthoDB; 163389at2759; -.
DR Proteomes; UP000002277; Chromosome 10.
DR Bgee; ENSPTRG00000002346; Expressed in testis and 20 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd20901; CC_AF10; 1.
DR CDD; cd15708; ePHD_AF10; 1.
DR CDD; cd15574; PHD_AF10_AF17; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR049773; AF10-like_CC.
DR InterPro; IPR049781; AF10/AF17_PHD.
DR InterPro; IPR049775; AF10_ePHD.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF93; PROTEIN AF-10; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 22..74
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 79..198
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 134..197
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 206..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 742..779
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 291..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1070 AA; 113588 MW; F3B6C2B706828BEA CRC64;
MVSSDRPVSL EDEVSHSMKE MIGGCCVCSD ERGWAENPLV YCDGHGCSVA VHQACYGIVQ
VPTGPWFCRK CESQERAARV RCELCPHKDG ALKRTDNGGW AHVVCALYIP EVQFANVSTM
EPIVLQSVPH DRYNKTCYIC DEQGRESKAA TGACMTCNKH GCRQAFHVTC AQFAGLLCEE
EGNGADNVQY CGYCKYHFSK LKKSKRGSNR SYDQSLSDSS SHSQDKHHEK EKKKYKEKDK
HKQKHKKQPE PSPALVPSLT VTTEKTYTST SNNSISGSLK RLEDTTARFT NANFQEVSAH
TSSGKDVSET RGSEGKGKKS SAHSSGQRGR KPGGGRNPGT TVSAASPFPQ GSFSGTPGSV
KSSSGSSVQS PQDFLSFTDS DLRNDSYSHS QQSSTTKDVH KGESGSQEGG VNSFSTLIGL
PSTSAVTSQP KSFENSPGDL GNSSLPTAGY KRAQTSGIEE ETVKEKKRKG NKQSKHGPGR
PKGNKNQENV SHLSVSSASP TSSVASAAGS ITSSSLQKSP TLLRNGSLQS LSVGSSPVGS
EISMQYRHDG ACPTTTFSEL LNAIHNGIYN SNDVAVSFPN VVSGSGSSTP VSSSHLPQQS
SGHLQQVGAL SPSAVSSAAP AVATTQANTL SGSSLSQAPS HMYGNRLNPN SSMAALIAQS
ENNQTDQDLG DNSRNLVGRG SSPRGSLSPR SPVSSLQIRY DQPGNSSLEN LPPVAASIEQ
LLERQWSEGQ QFLLEQGTPS DILGMLKSLH QLQVENRRLE EQIKNLTAKK ERLQLLNAQL
SVPFPTITAN PSPSHQIHTF SAQTAPTTDS LNSSKSPHIG NSFLPDNSLP VLNQDLTSSG
QSTSSSSALS TPPPAGQSPA QQGSGVSGVQ QVNGVTVGAL ASGMQPVTST IPAVSAVGGI
IGALPGNQLA INGIVGALNG VMQTPVTMSQ NPTPLTHTTV PPNATHPMPA TLTNSASGLG
LLSDQQRQIL IHQQQFQQLL NSQQLTPEQH QAFLYQLMQH HHQQHHQPEL QQLQIPGPTQ
IPINNLLAGT QAPPLHTATT NPFLTIHGDN ASQKVARLSD KTGPVAQEKS
//
