ID   K7D5D0_PANTR            Unreviewed;      1369 AA.
AC   K7D5D0;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=NLR family, pyrin domain containing 1 {ECO:0000313|EMBL:JAA27822.1};
GN   Name=NLRP1 {ECO:0000313|EMBL:JAA27822.1};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA27822.1};
RN   [1] {ECO:0000313|EMBL:JAA27822.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Skin {ECO:0000313|EMBL:JAA27822.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT   mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the NLRP family.
CC       {ECO:0000256|ARBA:ARBA00008665}.
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DR   EMBL; GABD01005278; JAA27822.1; -; mRNA.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   CDD; cd08320; Pyrin_NALPs; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR025307; FIIND_dom.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR46985:SF3; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF13553; FIIND; 1.
DR   Pfam; PF00560; LRR_1; 1.
DR   Pfam; PF13516; LRR_6; 2.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM00368; LRR_RI; 5.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50824; DAPIN; 1.
DR   PROSITE; PS51830; FIIND; 1.
DR   PROSITE; PS51450; LRR; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614}.
FT   DOMAIN          1..92
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          328..637
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   DOMAIN          1077..1362
FT                   /note="FIIND"
FT                   /evidence="ECO:0000259|PROSITE:PS51830"
FT   REGION          86..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          160..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..187
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        215..231
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1369 AA;  154136 MW;  FF397AC7AEAE5D25 CRC64;
     MAGGAWGRLA CYLEFLKKEE LKEFQLLLAN KAHSRSSSGE TPAQPEKTSG MEVASYLVAQ
     YGEQRAWDLA LHTWEQMGLR SLCTQAQEGA GHSPSFPYSP SEPHLGSPSQ PTSTAVLMPW
     IHELPAGCTQ GSERRVLRQL PDTSGRRWRE ISASLLYQAL PSSPDHESPS QESPNAPTST
     AVLGSWGSPP QPSLAPREQE APGTQWPLDE TSGIYYTEIR EREREKSEKG RPPWAAVVGT
     PPQAHASLQP HHHPWEPSVR ESLCSTWPWK NEDLNQKFTQ LLLLQRPHPR SQDPLVKRSW
     PDYVEENRGH LIEIRDLFGP GLDTQEPRVV ILQGAAGIGK STLARQVKEA WGRGQLYGDR
     FQHVFYFSCR ELAQSKVVSL AELIGKDGTA TPAPIRQILS RPERLLFILD GVDEPGWVLQ
     EPSSELCLHW SQPQPADALL GSLLGKTILP EASFLITART TALQNLIPSL EQARWVEVLG
     FSESSRKEYF YKYFTDERQA IRAFRLVKSN KELWALCLVP WVSWLACTCL MQQMKQKEKL
     TLTSKTTTTL CLHYLAQALQ AQPLGPQLRD LCSLAAEGIW QKKTLFSPDD LRKHGLDGAI
     ISTLLKMGIL QEHPIPLSYS FIHLCFQEFF AAMSYVLEDK KGRGKHSNCI IDLEKMLEAY
     GIHGLFGAST TRFLLGLLSD EGEREMENIF HCRLSQGRNL MQWVPSLQLL LQPHSLESLH
     CLYETRNKTF LTQVMAHFEE MGMCVETDME LLVCTFCIKF SHHVKKLQLI EGRQHRSTWS
     PTMVVLFRWV PVTDAYWQIL FSVLKVTRNL KELDLSGNLL SHSAVKSLCK TLRRPRCLLE
     TLRLAGCGLR AEDCKDLAFG LRANQALTEL DLSFNVLTDA GAKHLCQRLR QPSCKLQRLQ
     LVSCGLTSDC CQDLASVLSA SPSLKELDLQ QNNLDDVGVR LLCEGLRHPA CKLIHLGLDQ
     MTLSDEMRQE LRALEQEKPQ LLIFSRRKPS VMTPIEGLDT GEMSTSSLKR QRLGSERAAS
     HVAQANLKLL DVSKIFPIAE IAEESSPEVV PVELLCVPSP ASQGDLHMKP LGTDDDFWGP
     TGPVATEVVD KEKNLYRVHF PVAGSYRWPN TGLCFVVREA VTVEIEFCVW DQFLGEINPQ
     HSWMVAGPLL DIKAEPGAVE AVHLPHFVAL QGGHVDTSLF QVAHFKEEGM LLEKPARVEL
     HHIVLENPSF SPLGVLLKMI HNALRFIPVT SVVLLYHRLH PEEVTFHLYL IPSDCSIRKA
     IDDLEMKFQF VRIHKPPPLT PLYMGCRYTV SGSGSGMLEI LPKELELCYR SPGEDQLFSE
     FYVGHLGSGI RLQVKDKKDE TLVWEALVKP GRNTSQPWNL RCNRDARRC
//