ID K7DNB8_PANTR Unreviewed; 1892 AA.
AC K7DNB8; A0A2J8KI25;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Asp (Abnormal spindle) homolog, microcephaly associated {ECO:0000313|EMBL:JAA44444.1};
DE SubName: Full=Assembly factor for spindle microtubules {ECO:0000313|Ensembl:ENSPTRP00000082709.1};
GN Name=ASPM {ECO:0000313|EMBL:JAA44444.1,
GN ECO:0000313|Ensembl:ENSPTRP00000082709.1,
GN ECO:0000313|VGNC:VGNC:52941};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA44444.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000082709.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA44444.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA09228.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA44444.1}, Skin {ECO:0000313|EMBL:JAA31888.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA17823.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000082709.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AACZ04071383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC182474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01002110; JAA09228.1; -; mRNA.
DR EMBL; GABF01004322; JAA17823.1; -; mRNA.
DR EMBL; GABD01001212; JAA31888.1; -; mRNA.
DR EMBL; GABE01000295; JAA44444.1; -; mRNA.
DR RefSeq; XP_016803919.1; XM_016948430.1.
DR Ensembl; ENSPTRT00000101746.1; ENSPTRP00000082709.1; ENSPTRG00000001807.7.
DR GeneID; 449566; -.
DR CTD; 259266; -.
DR VGNC; VGNC:52941; ASPM.
DR GeneTree; ENSGT00560000077332; -.
DR OrthoDB; 53079at2759; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000001807; Expressed in thymus and 9 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR CDD; cd21223; CH_ASPM_rpt1; 1.
DR CDD; cd21224; CH_ASPM_rpt2; 1.
DR Gene3D; 1.20.5.190; -; 5.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22706:SF1; ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR22706; UNCHARACTERIZED; 1.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 8.
DR SMART; SM00033; CH; 2.
DR SMART; SM00015; IQ; 12.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 6.
PE 2: Evidence at transcript level;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 920..1056
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1110..1261
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1892 AA; 217776 MW; 1DD12138C69BBB98 CRC64;
MANRRVGRGC WEVSPTERRP PAGLRGPAAE EEASSPPVLS LSHFCRSPFL CFGDVLLGAS
RTLSLALDNP NEEVAEVKIS HFPAADLGFS VSQRCFVLQP KEKIVISVNW TPLKEGRVRE
IMTFLVNDVL KHQAILLGNA EEQKKKKRSL WDTIKKKKIS ASTSHNRRVS NIQNVNKTFS
VSQKVDRVRS PLQACENLAM NEGGPPTENN SLILEENKIP ISPISPAFNE CHGATCLPLS
VRRSTTYSSL HASENRELLN VHSANVSKVS FNEKAVTETS FNSVNVNGQS GENSKLSLTP
NYSSTLNITQ SQTHFLSPDS FVNNSHGANN ELELVTCLSS DMFMKDNSKP VHLESTIAHE
IYQKILSPDS FIKDNYGLNQ DLESESVNPI LSPNQFLKDN MAYMCTSQQT CKVPLSNENS
QVPQSPEDWR KSEVSPRIPE CQGSKSPKAI FEELVEMKSN YYSFIKQNNP KFSAVQDISS
HSHNKQPKRR PILSATVTKR KATCTRENQT EINKPKAKRC LNSAVGEHEK VINNQKEKED
FHSYLPIIDP ILSKSKSYKN EVTPSSTTAS VARKRKSDGS MEDGNVRVAI TEHTEVREIK
RIHFSPSEPK TSAVKKTKNV ITPISKRISN REKLNLKKKT DLSIFRTPIS KTNKRTKPII
AVAQSSLTFI KPLKTDIPRH PMPFAAKNMF YDERWKEKQE QGFTWWLNFI LTPDDFTVKT
NISEVNAATL LLGIENQHKI SVPRAPTKEE MSLRAYTARC RLNRLRRAAC RLFTSEKMVK
AIKKLEIEIE ARRLIVRKDR HLWKDVGERQ KVLNWLLSYN PLWLRIGLET TYGELISLED
NSDVTGLAMF ILNRLLWNPD IAAEYRHPSV PHLYRDGHEE VLSKFTLKKL LLLVCFLDYA
KISRLIDHDP CLFCKDAEFK ASKEILLAFS RDFLSGEGDL SRHLGLLGLP VNHVQTPFDE
FDFAVTNLAV DLQCGVRLVR TMELLTQNWD LSKKLRIPAI SRLQKMHNVD IVLQVLKSRG
IELSDEHGNT ILSKDIVDRH REKTLRLLWK IAFAFQVDIS LNLDQLKEEI AFLKHTKSIK
KTISLLSCHS DDLINKKKGK RDCGSFEQYS ENIKLLMDWV NAVCAFYNKK VENFTVSFSD
GRVLCYLIHH YHPCYVPFDA ICQRTTQTVE CTQTGSVVLN SSSESDDSSL DMSLKAFDHE
NTSELYKELL ENEKKNFHLV RSAVRDLGGI PAMINHSDMS NTIPDEKVVI TYLSFLCARL
LDLRKEIRAA RLIQTTWRKY KLKTDLKRHQ EREKAARIIQ LAVINFLAKQ RLRKRVNAAL
VIQKYWRRVL AQRKLLMLKK EKLEKVQNKA ASLIQAMWRR YRAKKYLCKV KAACKIQAWY
RCWRAHKEYL AILKAVKIIQ GCFYTKLERT RFLNVRASAI IIQRKWRAIL SAKIAHEHFL
MIKRHRAACL IQAHYRGYKG RQVFLRQKSA ALIIQKYIRA REAGKRERIK YIEFKKSTVI
LQALVRGWLV RKRILEQRAK IRLLHFTAAA YYHLNAVRIQ RAYKLYLAVK NANKQVNSVI
CIQRWFRARL QEKRFIQKYH SIKKIEHEGQ ECLSQRNRAA SVIQKAVRHF LLRKKQEKFT
SGIIKIQALW RGYSWRKKND CTKIKAIRLS LQVVNREIRE ENKLYKRTAL ALHYLLTYKH
LSAILEALKH LEVVTRLSPL CCENMAQSGA ISKIFVLIRS CNRSIPCMEV IRYAVQVLLN
VSKYEKTTSA VYDVENCIDI LLELLQIYRE KPGNKVADKG GSIFTKTCCL LAILLKTTNR
ASDVRSRSKV VDRIYSLYKL TAHKHKMNTE RILYKQKKNS SISIPFIPET PVRTRIVSRL
KPDWVLRRDN MEEITNPLQA IQMVMDTLGI PY
//
