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Database: UniProt
Entry: K7E657_MONDO
LinkDB: K7E657_MONDO
Original site: K7E657_MONDO 
ID   K7E657_MONDO            Unreviewed;      1825 AA.
AC   K7E657;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   25-OCT-2017, entry version 39.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN7A {ECO:0000313|Ensembl:ENSMODP00000041259};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000041259, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000041259, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000041259}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000041259}.
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DR   STRING; 13616.ENSMODP00000041259; -.
DR   Ensembl; ENSMODT00000044367; ENSMODP00000041259; ENSMODG00000028392.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410Y1Z2; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; K7E657; -.
DR   OMA; DLAIVIC; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000002280; Chromosome 4.
DR   Bgee; ENSMODG00000028392; -.
DR   GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR028803; SCN9A.
DR   PANTHER; PTHR10037:SF221; PTHR10037:SF221; 2.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    112    131       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    137    158       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    179    207       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    227    249       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    357    383       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    588    609       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    615    639       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    651    668       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    674    692       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    713    735       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    792    818       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1041   1061       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1073   1093       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1105   1125       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1163   1183       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1283   1306       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1361   1379       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1391   1413       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1425   1444       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1488   1514       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1526   1545       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1582   1608       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      111    389       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      587    820       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      830   1032       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1036   1314       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1361   1614       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1619   1678       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      445    477       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1825 AA;  209736 MW;  677F3EF231DFF022 CRC64;
     MARPQNLTYF TKKSLALAEE RAAARKSDED ELEPNSDFEA GKKLPFIYDD VPPGMVSEPL
     EDLDPYYLDK NTFIVLDKGK TIFRFNASPA LYFLTPFHFI RRLSIKILMN PLFNMILMGT
     FLINCIFLPA INIPDWMVYL ELPFIGLYTF EILIKILARG FCMKPFTFLR DPWNWLDGHI
     LFYALLTLFI NLDSVSALGI FSVVRILKAT SLTTGTKIII GTLTRSVRMF CHAVILIMFC
     LSVFAVMGMQ LFMDRLKQKC VPWPQEQNST EILSGNETLS SYHLEEQMHA LLCGNTSFSG
     RCPKGYLCVK TGGNPDYGYT NFDSFGWAFL SLFRLMTLDF WESLYQQILR TSGKESVIFF
     VFVIFFCSFY LVSLKLAVVA MAYEKQNQAT IKAAKRKQVK YQAMLCRHKR DQEETEAMTA
     VGAEKKNGKD LSSADASSGI SDHTNERMEQ RKKENQEKDA EREEKEIDAK LHQFESEDFI
     RKKVFHHGIN SKQMQKTAPF TEEGSTLQAD KKERQINTCQ VSMGILEDPD VGKRSMSKAN
     VLNSSEGLDK CRPRRLWKRF AKMFLIWDCC PFWLKCKDFV YSIVMDPFFD LAIVICVIMN
     LVFLAMNHYP MTEEFLYVLS VGELVFVGIY ILEMVLKIIA LHPYNYFQDK WNIFDSFIVT
     LALGELMLSI FDEAYFSFLQ FLILLRGLRV FKLTKYWPTM KMMINILGYS VKALRSLTLV
     LFITIFIFAV IGLKFVQHFP NEYLCKIDID CFPRWHMYDI IHSFLVVFRA LSGEWIETMW
     DCMEIAGQPT CLIFYTGIIV IGNLLVLILF VALLSSFISE NSAMSDVKAD SQNLHLAIGR
     IKRGIHYVKR TLFDLIGEVF SKKQTISKET QREENLRMKK KNGTSRQSAN KMSNEQDLQN
     DKEGTSASGS NMEKHLRDNN SSQSSLHNPI HPMPAPIALA EFDSENVNTK EFRNELDVDG
     SNEKLSHTIS PEDSMIPILG SEEEEVMTGS EKSDEPGPCF SDGCIRWFPF CGASMKSKRG
     KIWWNLRKSC YRIVKHRCFE MFMFLIILLS CYALTYEDIY IEDRKTIKIV LEYADNIFTY
     IFITEMLLKW LAYGCKGYFS NTWCWLEFLV VNVCFFNLLG NYLGYIEFAA LKSLRTLRIL
     SVFKRVRVVL NTLVREIPSI LKVLLVGLTF WLIFNIIGVN LFAGKFYDCI NTTSGESLSV
     YDGVQNKSEC EQLMYSSKAV NMRNSSGDVL WKNAKMNFDN VKNGYLSLFQ LATFKGWLDV
     MYSAVDSTSV EKPPRFEFSF YTYFYFVGFI IFGVFFPLVL FIGVIIDNFK QQKKIRGESI
     FMTEDQKKSY NSKKNPRYKN PIPRPRNKFQ GYIFDLVTKE AFEITILVLI CLNVVIMMME
     TNSDSDYKIM ILRLIDLVFI ILFAGECVLK LIGLRHHYFS TGWNIFDFVV VHISIAVVLL
     NNLTEKYLLT YAQMQVIRFI RCGRVLNYIK GTKGMGTLIS AMMLSLPALL NIVLLLFLVM
     VIYAVIGMSQ FAYIKKEAGI DDMFNFETFV NSMLCLFQIT TFAGWDGLLI PVLNTGPPDC
     DPEKIHPGSS VRGDCGSPSF GVFYFVSYII ISFLLFVNMF IVVIFEILSA VSEENSKSLS
     EEAFDNFYEV WQKFDPDTTH FIDHSQLSDF AASLAPPLLI PKPNTKQLMA MDLPLAKGDR
     VFCPDVLFAL AKRVKGESEE FDHLHLPMRE QFLSSCLFQI SYEPVSTIKQ KQEEVSAPVI
     PHALKEHDSD TCNNKDGDRE DPTFKDNIIF DRVNENSALE KAGDVSDSPT LIASLCNIIE
     QERENHETNQ AEKEDNGKGD REKEK
//
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