ID K7EKY9_HUMAN Unreviewed; 255 AA.
AC K7EKY9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 8.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Protein kinase N1 {ECO:0000313|Ensembl:ENSP00000465842.1};
DE Flags: Fragment;
GN Name=PKN1 {ECO:0000313|Ensembl:ENSP00000465842.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000465842.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000465842.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [4] {ECO:0000313|Ensembl:ENSP00000465842.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC008569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7EKY9; -.
DR SMR; K7EKY9; -.
DR MassIVE; K7EKY9; -.
DR PeptideAtlas; K7EKY9; -.
DR Antibodypedia; 1296; 301 antibodies from 34 providers.
DR Ensembl; ENST00000586557.5; ENSP00000465842.1; ENSG00000123143.13.
DR UCSC; uc060uoe.1; human.
DR HGNC; HGNC:9405; PKN1.
DR VEuPathDB; HostDB:ENSG00000123143; -.
DR GeneTree; ENSGT00940000154990; -.
DR ChiTaRS; PKN1; human.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000123143; Expressed in apex of heart and 142 other cell types or tissues.
DR ExpressionAtlas; K7EKY9; baseline and differential.
DR GO; GO:0004697; F:diacylglycerol-dependent serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd11630; HR1_PKN1_2; 1.
DR CDD; cd11622; HR1_PKN_1; 1.
DR Gene3D; 1.10.287.160; HR1 repeat; 2.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036274; HR1_rpt_sf.
DR InterPro; IPR037317; PKN1_HR1_2.
DR InterPro; IPR037313; PKN_HR1_1.
DR Pfam; PF02185; HR1; 2.
DR SMART; SM00742; Hr1; 2.
DR SUPFAM; SSF46585; HR1 repeat; 2.
DR PROSITE; PS51860; REM_1; 2.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01207, ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|EPD:K7EKY9,
KW ECO:0007829|MaxQB:K7EKY9};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 37..112
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT DOMAIN 124..205
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT REGION 114..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 44..71
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 255
FT /evidence="ECO:0000313|Ensembl:ENSP00000465842.1"
SQ SEQUENCE 255 AA; 28205 MW; 4E54F108C264F65B CRC64;
MACRPCRGAG RIWCCRSHKS EPRSWSLLEQ LGLAGADLAA PGVQQQLELE RERLRREIRK
ELKLKEGAEN LRRATTDLGR SLGPVELLLR GSSRRLDLLH QQLQELHAHV VLPDPAATHD
GPQSPGAGGP TCSATNLSRV AGLEKQLAIE LKVKQGAENM IQTYSNGSTK DRKLLLTAQQ
MLQDSKTKID IIRMQLRRAL QAGQLENQAA PDDTQGEVST VLKLDNTVVG QTSWKPCGPN
AWDQSFTLEL ERARE
//
