ID K7EMK7_HUMAN Unreviewed; 744 AA.
AC K7EMK7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=TLE family member 2, transcriptional corepressor {ECO:0000313|Ensembl:ENSP00000466542.1};
GN Name=TLE2 {ECO:0000313|Ensembl:ENSP00000466542.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466542.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000466542.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0007829|PubMed:18669648}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [3] {ECO:0007829|PubMed:19690332}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [4] {ECO:0000313|Ensembl:ENSP00000466542.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR EMBL; AC007766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC011549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001287775.1; NM_001300846.1.
DR AlphaFoldDB; K7EMK7; -.
DR SMR; K7EMK7; -.
DR MassIVE; K7EMK7; -.
DR PeptideAtlas; K7EMK7; -.
DR Antibodypedia; 23107; 227 antibodies from 31 providers.
DR DNASU; 7089; -.
DR Ensembl; ENST00000590536.5; ENSP00000466542.1; ENSG00000065717.16.
DR GeneID; 7089; -.
DR UCSC; uc010dth.4; human.
DR CTD; 7089; -.
DR HGNC; HGNC:11838; TLE2.
DR VEuPathDB; HostDB:ENSG00000065717; -.
DR GeneTree; ENSGT01030000234519; -.
DR OMA; CTDISND; -.
DR OrthoDB; 1333122at2759; -.
DR PhylomeDB; K7EMK7; -.
DR BioGRID-ORCS; 7089; 28 hits in 1160 CRISPR screens.
DR ChiTaRS; TLE2; human.
DR GenomeRNAi; 7089; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000065717; Expressed in cerebellar hemisphere and 204 other cell types or tissues.
DR ExpressionAtlas; K7EMK7; baseline and differential.
DR GO; GO:0005925; C:focal adhesion; IDA:HPA.
DR GO; GO:0016604; C:nuclear body; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF4; TRANSDUCIN-LIKE ENHANCER PROTEIN 2; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|PeptideAtlas:K7EMK7,
KW ECO:0007829|ProteomicsDB:K7EMK7};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 17..128
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 544..585
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 586..627
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 668..699
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 180..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 25..52
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 215..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 744 AA; 79969 MW; AD54C5FE19C67D76 CRC64;
MYPQGRHPTP LQSGQPFKFS ILEICDRIKE EFQFLQAQYH SLKLECEKLA SEKTEMQRHY
VMYYEMSYGL NIEMHKQAEI VKRLSGICAQ IIPFLTQEHQ QQVLQAVERA KQVTVGELNS
LIGQQQLQPL SHHAPPVPLT PRPAGLVGGS ATGLLALSGA LAAQAQLAAA VKEDRAGVEA
EGSRVERAPS RSASPSPPES LVEEERPSGP GGGGKQRADE KEPSGPYESD EDKSDYNLVV
DEDQPSEPPS PATTPCGKVP ICIPARRDLV DSPASLASSL GSPLPRAKEL ILNDLPASTP
ASKSCDSSPP QDASTPGPSS ASHLCQLAAK PAPSTDSVAL RSPLTLSSPF TTSFSLGSHS
TLNGDLSVPS SYVSLHLSPQ VSSSVVYGRS PVMAFESHPH LRGSSVSSSL PSIPGGKPAY
SFHVSADGQM QPVPFPSDAL VGAGIPRHAR QLHTLAHGEV VCAVTISGST QHVYTGGKGC
VKVWDVGQPG AKTPVAQLDC LNRDNYIRSC KLLPDGRSLI VGGEASTLSI WDLAAPTPRI
KAELTSSAPA CYALAVSPDA KVCFSCCSDG NIVVWDLQNQ TMVRQFQGHT DGASCIDISD
YGTRLWTGGL DNTVRCWDLR EGRQLQQHDF SSQIFSLGHC PNQDWLAVGM ESSNVEILHV
RKPEKYQLHL HESCVLSLKF ASCGRWFVST GKDNLLNAWR TPYGASIFQS KESSSVLSCD
ISRNNKYIVT GSGDKKATVY EVVY
//
