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Database: UniProt
Entry: K7ENA1_HUMAN
LinkDB: K7ENA1_HUMAN
Original site: K7ENA1_HUMAN 
ID   K7ENA1_HUMAN            Unreviewed;       191 AA.
AC   K7ENA1;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-SEP-2017, entry version 29.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
DE   Flags: Fragment;
GN   Name=ATP6V0A1 {ECO:0000313|Ensembl:ENSP00000466852};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466852, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000466852, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000466852}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSP00000466852}.
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DR   EMBL; AC067852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC107993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7ENA1; -.
DR   PeptideAtlas; K7ENA1; -.
DR   Ensembl; ENST00000588138; ENSP00000466852; ENSG00000033627.
DR   UCSC; uc060fjh.1; human.
DR   EuPathDB; HostDB:ENSG00000033627.14; -.
DR   HGNC; HGNC:865; ATP6V0A1.
DR   OpenTargets; ENSG00000033627; -.
DR   GeneTree; ENSGT00390000004941; -.
DR   ChiTaRS; ATP6V0A1; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000033627; -.
DR   ExpressionAtlas; K7ENA1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:K7ENA1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    148    171       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000466852}.
FT   NON_TER     191    191       {ECO:0000313|Ensembl:ENSP00000466852}.
SQ   SEQUENCE   191 AA;  21182 MW;  480609384A5297C6 CRC64;
     PWMLLFKPLV LRRQYLRRKH LEGQPVEAPV SPNPSQQGLE AAAAATGTLN FGGIRVGNGP
     TEEDAEIIQH DQLSTHSEDA DEPSEDEVFD FGDTMVHQAI HTIEYCLGCI SNTASYLRLW
     ALSLAHAQLS EVLWTMVIHI GLSVKSLAGG LVLFFFFTAF ATLTVAILLI MEGLSAFLHA
     LRLHWVEFQN K
//
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