ID K7EQB2_HUMAN Unreviewed; 185 AA.
AC K7EQB2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 8.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Glyoxylate reductase 1 homolog {ECO:0000313|Ensembl:ENSP00000467751.1};
DE Flags: Fragment;
GN Name=GLYR1 {ECO:0000313|Ensembl:ENSP00000467751.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000467751.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000467751.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0007829|PubMed:28112733}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
RN [4] {ECO:0000313|Ensembl:ENSP00000467751.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC020663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF456151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7EQB2; -.
DR SMR; K7EQB2; -.
DR MassIVE; K7EQB2; -.
DR PeptideAtlas; K7EQB2; -.
DR Antibodypedia; 24437; 134 antibodies from 22 providers.
DR Ensembl; ENST00000588297.5; ENSP00000467751.1; ENSG00000140632.17.
DR UCSC; uc059qke.1; human.
DR HGNC; HGNC:24434; GLYR1.
DR VEuPathDB; HostDB:ENSG00000140632; -.
DR GeneTree; ENSGT00940000156435; -.
DR HOGENOM; CLU_1464478_0_0_1; -.
DR ChiTaRS; GLYR1; human.
DR Proteomes; UP000005640; Chromosome 16.
DR Bgee; ENSG00000140632; Expressed in monocyte and 198 other cell types or tissues.
DR ExpressionAtlas; K7EQB2; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR CDD; cd05836; PWWP_GLYR1; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR InterPro; IPR035501; GLYR1_PWWP.
DR InterPro; IPR000313; PWWP_dom.
DR PANTHER; PTHR10688; PWWP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10688:SF5; PWWP DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:K7EQB2,
KW ECO:0007829|MaxQB:K7EQB2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 8..66
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT NON_TER 185
FT /evidence="ECO:0000313|Ensembl:ENSP00000467751.1"
SQ SEQUENCE 185 AA; 20473 MW; A929670F1EC6C75F CRC64;
MAAVSLRLGD LVWGKLGRYP PWPGKIVNPP KDLKKPRGKK CFFVKFFGTE DHAWIKVEQL
KPYHAHKEEM IKINKGKRFQ QAVDAVEEFL RRAKGKDQDL TIPESSTVKG MMAGPMAAFK
WQPTASEPVK DADPHFHHFL LSQTEKETGS TSIQAADSTA VNGSITPTDK KIGFLGLGLM
GSGIV
//
