ID K7EU17_PONAB Unreviewed; 1233 AA.
AC K7EU17; A0A2J8XQA8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=SEC24 homolog B, COPII coat complex component {ECO:0000313|Ensembl:ENSPPYP00000024040.2};
DE SubName: Full=SEC24B isoform 3 {ECO:0000313|EMBL:PNJ84201.1};
GN Name=SEC24B {ECO:0000313|Ensembl:ENSPPYP00000024040.2};
GN ORFNames=CR201_G0000548 {ECO:0000313|EMBL:PNJ84201.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000024040.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000024040.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ84201.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ84201.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000024040.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR EMBL; NDHI03003363; PNJ84201.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000024040; -.
DR Ensembl; ENSPPYT00000033304.2; ENSPPYP00000024040.2; ENSPPYG00000029772.2.
DR eggNOG; KOG1985; Eukaryota.
DR GeneTree; ENSGT00950000182924; -.
DR HOGENOM; CLU_004589_2_0_1; -.
DR TreeFam; TF354244; -.
DR Proteomes; UP000001595; Chromosome 4.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803:SF42; PROTEIN TRANSPORT PROTEIN SEC24B; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 567..603
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 640..879
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 884..968
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 979..1079
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 1106..1179
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..416
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1233 AA; 133727 MW; 8F799DBA11F51890 CRC64;
MSAPAGSSHP AASARIPPKF GGAAASGAAA PAGPGPGPAP HQQNGPAQNQ MQVPSGYGLH
HQNYIAPSGH YSQGPGKMTS LPLDTQCSDY YSALYTVPTQ NVTPNTVNQQ PGAQQMYSRG
PPAPHIVGST LGSFQGAALS ASHLHTSASQ PYSSFVNHYN SPAMYSANSS VASQGFPSTC
GHYAMSTVSS AAYPSVSYPS LPAGDTYGQM FTSQNAPTVR PVKDNSFSGQ NTAISHPSPL
PPPPSQQHHQ QQSLSGYSTL TWSAPGLPST QDNLIRNHTG SLAVANNNPT ITVADSLSCP
VMQNVQPPKS SPVVSTVLSG SSGSSSTRTP PTANHSVEPV TSVTQPSELL QQKGVDSSST
TSSASPMPNN YDALEGGSYP DMLSSSASSP APDPAPEPDP ASAPAPASAP APVVPQPSKM
AKPFGYGYPT LQPGYQNATA PLISGVQPSN PVYSGFQQYP QQYPGVNQLS SSIGGLSLQS
SPQPESLRPV NLTQERNILP MTPVWAPVPN LNADLKKLNC SPDSFRCTLT NIPQTQALLN
KAKLPLGLLL HPFRDLTQLP VITSNTIVRC RSCRTYINPF VSFIDQRRWK CNLCYRVNDV
PEEFMYNPLT RSYGEPHKRP EVQNSTVEFI ASSDYMLRPP QPAVYLFVLD VSHNAVEAGY
LTILCQSLLE NLDKLPGDSR TRIGFMTFDS TIHFYNLQEG LSQPQMLIVS DIDDVFLPTP
DSLLVNLYES KELIKDLLNA LPNMFTNTRE THSALGPALQ AAFKLMSPTG GRVSVFQTQL
PSLGAGLLQS REDPNQRSST KVVQHLGPAT DFYKKLALDC SGQQTAVDLF LLSSQYSDLA
SLACMSKYSA GCIYYYPSFH YTHNPSQAEK LQKDLKRYLT RKIGFEAVMR IRCTKGLSMH
TFHGNFFVRS TDLLSLANIN PDAGFAVQLS IEESLTDTSL VCFQTALLYT SSKGERRIRV
HTLCLPVVSS LADVYAGVDV QAAICLLANM AVDRSVSSSL SDARDALVNA VVDSLSAYGS
TVSNLQHSAL MAPSSLKLFP LYVLALLKQK AFRTGTSTRL DDRVYAMCQI KSQPLVHLMK
MIHPNLYRID RLTDEGAVHV NDRVVPQPPL QKLSAEKLTR EGAFLMDCGS VFYIWVGKGC
DNNFIEDVLG YRNFASIPQK MTHLPELDTL SSERARSFIT WLRDSRPLSP ILHIVKDESP
AKAEFFQHLI EDRTEAAFSY YEFLLHVQQQ ICK
//
