ID K7EUI9_PONAB Unreviewed; 590 AA.
AC K7EUI9; A0A2J8WNC1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=KDM1B isoform 2 {ECO:0000313|EMBL:PNJ71265.1};
DE SubName: Full=Lysine demethylase 1B {ECO:0000313|Ensembl:ENSPPYP00000024214.2};
GN Name=KDM1B {ECO:0000313|Ensembl:ENSPPYP00000024214.2};
GN ORFNames=CR201_G0009461 {ECO:0000313|EMBL:PNJ71265.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000024214.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000024214.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ71265.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ71265.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000024214.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; NDHI03003384; PNJ71265.1; -; Genomic_DNA.
DR Ensembl; ENSPPYT00000033476.2; ENSPPYP00000024214.2; ENSPPYG00000016264.3.
DR GeneTree; ENSGT00940000157751; -.
DR HOGENOM; CLU_007885_0_0_1; -.
DR Proteomes; UP000001595; Chromosome 6.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.100; -; 1.
DR Gene3D; 3.90.660.10; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR011124; Znf_CW.
DR PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR PANTHER; PTHR10742:SF413; LYSINE-SPECIFIC HISTONE DEMETHYLASE 1B; 1.
DR Pfam; PF01593; Amino_oxidase; 2.
DR Pfam; PF07496; zf-CW; 1.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS51050; ZF_CW; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00454}.
FT DOMAIN 133..193
FT /note="CW-type"
FT /evidence="ECO:0000259|PROSITE:PS51050"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 590 AA; 65673 MW; 8A8894E79983017D CRC64;
MATPRGRTKK KASFDHSPDS LPLRSSGRQA KKKATETTDE DEDGGSEKKY RKCEKAGCTA
TCPVCFASAS ERCAKNGYTS RWYHLSCGEH FCNECFDHYY RSHKDGYDKY TTWKKIWTSN
GKTEPSPKAF MADQQLPYWV QCTKPECRKW RQLTKEIQLT PQIAKTYRCG MKPNTAIKPE
TSDHCSLPED LEALTPQKCI PHIIVRGLVR IRCVQEVERI LYFMTRKGLI NTGVLSVGAD
QYLLPKDYHN KSVIIIGAGP AGLAAAKQLH NFGIKVTVLE AKDRIGGRVW DDKSFKGVTV
GRGAQIVNGC INNPVALMCE QVSARSWDHN EFFAQFAGDH TLLTPGYSVI IEKLAEGLDI
RLKSPVQCID YSGGEVQVTT TDGTGYSAQK VLVTVPLALL QKGAIQFNPP LSEKKMKAIN
SLGAGIIEKI ALQFPYRFWD SKVQGADFFG HVPPSASKRG LFAVFYDMDP QKKHSVLMSV
IAGEAVASVR TLEDKQVLQQ CMATLRELFK EQEVPDPTKY FVTRWSTDPW IQMAYSFVKT
GGSGEAYDII AEDIQGTVFF AGEATNRHFP QTVTGAYLSG VREASKIAAF
//
