ID K7EXS4_PELSI Unreviewed; 330 AA.
AC K7EXS4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 3C {ECO:0000256|PIRNR:PIRNR038207};
GN Name=PPP1R3C {ECO:0000313|Ensembl:ENSPSIP00000000584.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000000584.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000000584.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a glycogen-targeting subunit for PP1 and regulates
CC its activity. Activates glycogen synthase, reduces glycogen
CC phosphorylase activity and limits glycogen breakdown.
CC {ECO:0000256|PIRNR:PIRNR038207}.
CC -!- SUBUNIT: Interacts with PPP1CC catalytic subunit of PP1 and associates
CC with glycogen. Forms complexes with glycogen phosphorylase, glycogen
CC synthase and phosphorylase kinase which is necessary for its regulation
CC of PP1 activity. {ECO:0000256|PIRNR:PIRNR038207}.
CC -!- DOMAIN: The N-terminal region is required for binding to PP1, the
CC central region is required for binding to glycogen and the C-terminal
CC region is required for binding to glycogen phosphorylase glycogen
CC synthase and phosphorylase kinase. {ECO:0000256|PIRNR:PIRNR038207}.
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DR EMBL; AGCU01048617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01048618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 13735.ENSPSIP00000000584; -.
DR Ensembl; ENSPSIT00000000584.1; ENSPSIP00000000584.1; ENSPSIG00000000584.1.
DR eggNOG; KOG3986; Eukaryota.
DR GeneTree; ENSGT00940000155648; -.
DR HOGENOM; CLU_040215_2_1_1; -.
DR TreeFam; TF105537; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:2001069; F:glycogen binding; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0019903; F:protein phosphatase binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd22815; PBD_PPP1R3C; 1.
DR Gene3D; 2.60.40.2440; Carbohydrate binding type-21 domain; 1.
DR InterPro; IPR005036; CBM21_dom.
DR InterPro; IPR038175; CBM21_dom_sf.
DR InterPro; IPR017434; Pase-1_reg-su_3B/C/D_met.
DR InterPro; IPR030683; PP1_3C.
DR PANTHER; PTHR12307; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR12307:SF15; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3C; 1.
DR Pfam; PF03370; CBM_21; 1.
DR PIRSF; PIRSF038207; PP1_GT_animal; 1.
DR PIRSF; PIRSF500813; PP1_PTG; 1.
DR PROSITE; PS51159; CBM21; 1.
PE 4: Predicted;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277,
KW ECO:0000256|PIRNR:PIRNR038207};
KW Glycogen metabolism {ECO:0000256|ARBA:ARBA00022600,
KW ECO:0000256|PIRNR:PIRNR038207};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 146..254
FT /note="CBM21"
FT /evidence="ECO:0000259|PROSITE:PS51159"
SQ SEQUENCE 330 AA; 38114 MW; 2C390E4ACA163701 CRC64;
MIQILDPRPL PSSIMPVDVA MRICLAHSPP LKRILSPLDD YPRRNFVNRF KPLRPCLNVK
RESECRNNSD WNRSPSRAKK RVVFADSKGL SLTAIHVFSE IQEHPVWDLQ FDLSDLEDIT
AGLKLHEERN LILGFPQPSA DYLDFRNRLQ KNFVCLENCT LQERAVAGTV KVKNMSYEKV
VQVRITFDTW KTYTDVDCVY MNNVYGDSDS DTFSFAIELP AAIPTQEKIE FCISYQSGKH
IFWDNNEGQN YKIVHAEWKP DGVQAPASTK RDCTVHKIPR MTQDCEQFGS PRMSNGLFPE
WQSWGRIENS APYWXXXXXX XXXXXXAFNH
//
