ID K7F367_PELSI Unreviewed; 567 AA.
AC K7F367;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=BRCA1 associated protein {ECO:0000313|Ensembl:ENSPSIP00000002477.1};
GN Name=BRAP {ECO:0000313|Ensembl:ENSPSIP00000002477.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000002477.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000002477.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01028595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01028596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7F367; -.
DR STRING; 13735.ENSPSIP00000002477; -.
DR Ensembl; ENSPSIT00000002486.1; ENSPSIP00000002477.1; ENSPSIG00000002430.1.
DR eggNOG; KOG0804; Eukaryota.
DR GeneTree; ENSGT00500000044909; -.
DR HOGENOM; CLU_009969_3_0_1; -.
DR OMA; SPNQYMA; -.
DR TreeFam; TF313622; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000151; C:ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0008139; F:nuclear localization sequence binding; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR GO; GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
DR CDD; cd16457; RING-H2_BRAP2; 1.
DR CDD; cd12718; RRM_BRAP2; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR011422; BRAP2/ETP1_RRM.
DR InterPro; IPR034932; BRAP2_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR047243; RING-H2_BRAP2.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001607; Znf_UBP.
DR PANTHER; PTHR24007; BRCA1-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR24007:SF7; BRCA1-ASSOCIATED PROTEIN; 1.
DR Pfam; PF07576; BRAP2; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR Pfam; PF02148; zf-UBP; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00290; ZnF_UBP; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50271; ZF_UBP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00502}.
FT DOMAIN 241..281
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 278..370
FT /note="UBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50271"
FT REGION 51..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 415..484
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 51..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 567 AA; 64799 MW; 899703BA0A8A5E82 CRC64;
ATEMSDEEIK DKSLASAAAC LEGKAPMEKA AIIHQHIGRR EMTDIIIETI KSNPEKDETQ
AAMEGRKTPE ASPVDDKSKC DGQTKECVEA APDSPSKQLP DQISFFSGNP SVEIVHGIMH
LYKTNKMTSL KEDVRRSAML CILTVPATMT SHDLMKFVAS FYEVIEHMKI IRDSTPNQYM
VLIKFSTQAD ADSFYMACNG RQFNSIEEDV CQLVYVERAE VFKSEDGASL PVMDLTELPK
CTVCLERMDE SVNGILTTVC NHSFHSQCLQ RWEDTTCPVC RYCQTPEPVE ENKCFECGVQ
ENLWICLICG HIGCGRYVSR HAYKHFEETQ HTYAMQLTNH RVWDYAGDNY VHRLVASKTD
GKIVQYECEG DMCQEEKIDS LQLEYSYLLT SQLESQRIYW ENKIVRIEKD TAEEINNMKT
KFKETIEKCD SLEHKLNNLL KEKQSLERKC MQLNNKVAKL SNELEEEQEM NKCLRANQVL
LQNKLKEEEK VLKETCEQKD LQITEIQEQL RDVMFYLETQ QKINHLPAET RQEIQGGQIN
IAVASSASSP AGSTGKPPRR GRSKRGK
//
