ID K7F4X0_PELSI Unreviewed; 536 AA.
AC K7F4X0;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Potassium voltage-gated channel subfamily H member 3 {ECO:0000313|Ensembl:ENSPSIP00000003080.1};
GN Name=KCNH3 {ECO:0000313|Ensembl:ENSPSIP00000003080.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000003080.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000003080.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AGCU01140617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01140618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01140619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01140620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7F4X0; -.
DR STRING; 13735.ENSPSIP00000003080; -.
DR Ensembl; ENSPSIT00000003093.1; ENSPSIP00000003080.1; ENSPSIG00000002968.1.
DR eggNOG; KOG0498; Eukaryota.
DR GeneTree; ENSGT00940000161742; -.
DR HOGENOM; CLU_005746_2_3_1; -.
DR OMA; HGSSHEL; -.
DR TreeFam; TF313130; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR003950; K_chnl_volt-dep_ELK.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR PANTHER; PTHR10217:SF481; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 3; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01465; ELKCHANNEL.
DR SMART; SM00086; PAC; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50113; PAC; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 237..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..75
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
SQ SEQUENCE 536 AA; 59803 MW; 9E7124785026168B CRC64;
YMPQQGRTLA PQKAKILEEH QEFKAELILY RKRGAPFWCL LDVVPIKNEK GEVALFLVSH
KDITDSKSRP GAESWKEAGG KRRFSRAGAK GFNANRRRSR AVLYHLSGHL QKQGKNKHKL
NKGVFGEKPS LPEYKVAAIH KSPFILLHYG AFRAGWDGLI LLATLYVAVT VPYSVCVGAG
SDEGLPAARG PPSVCDLCVE ILFILDIVLN FRTTFVSKSG QVVFDPHAIS LHYLTGWFLL
DLVAALPFDL LYAFKVNVYF GAHLLKTVRL LRLLRLLPNL DRYSQYSAVV LTLLMIVFAL
LAHWVACVWF FIGRLEIESS RAELPEIGWL QRLARRLETP YYLARKSCSS PANRTGPTLP
PSHTATLTRH PIPLARQSHT ASCSPCTAPL AQSPTLPTAL MHAVVFGNVT AIIQRMYARR
FLYHSRTRDL HDFIRIHRIP KPLRQRMLEL CGLSEPRAEA VPRKSCIARG GTRLGISDPP
SVLGKGDLLG CELSAQECVI KANADVKGLT YCDLQCLSLR GLGESMALYP EFACKF
//
