ID K7F6D0_PELSI Unreviewed; 522 AA.
AC K7F6D0;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 {ECO:0000313|Ensembl:ENSPSIP00000003590.1};
GN Name=HCN2 {ECO:0000313|Ensembl:ENSPSIP00000003590.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000003590.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000003590.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGCU01112828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01112829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01112830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01112831; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01112832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01112833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01112834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01112835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7F6D0; -.
DR Ensembl; ENSPSIT00000003609.1; ENSPSIP00000003590.1; ENSPSIG00000003416.1.
DR eggNOG; KOG0498; Eukaryota.
DR GeneTree; ENSGT00940000156523; -.
DR HOGENOM; CLU_005746_15_2_1; -.
DR TreeFam; TF318250; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0098855; C:HCN channel complex; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005222; F:intracellular cAMP-activated cation channel activity; IEA:Ensembl.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:Ensembl.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR GO; GO:0071321; P:cellular response to cGMP; IEA:Ensembl.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:Ensembl.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF11; POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 32..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..144
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 288..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..431
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 57459 MW; F18504D0DBA9DD53 CRC64;
RFYWDFTMLL FMVGNLIIIP VGITFFKEET TAPWIVFNVV SDTFFLMDLV LNFRTGIVIE
DNTDIILDPE RIKKKYLKTW FVVDFVSSIP VDYIFLIVEK GIDSEVYKTA RALRIVRFTK
ILSLLRVLRL SRLIRYIHQW EETMSQGYHL PKGVPAGLCL RVHVAVAMCA WYGWACVCGL
VPSVSRWHSH CQVRVDGKCN NSWSELYSFA LFILGCCGWG AGIGAEQVPD PASSRGTAVM
SSLFRGPGYE VFYCRDGSLC KSIAPARRAA CGDTRAGDST CNWHRLPVSR KPEESKPPDV
RGLPRGISET DGRTQAAGSF RQLAWGRMGG APLQRCPGCA SWDPGASPSP RTDPRLKGVP
GSLPLPSPST AGPGTELPAG VSGGARRGGG QGGRGARPVC SWAACCFSSR LRSDSPPALR
PPREEEFDPA AQSPARPELW GVTHLLLYAP PGKKNSILLH KVQHDLNSGV FNNQENEIIQ
EIVKYDREMV QQAELQQHPG LYAPVQPQVT SAIATLQQAG AM
//
