ID K7F7C6_PELSI Unreviewed; 1622 AA.
AC K7F7C6;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Pappalysin 1 {ECO:0000313|Ensembl:ENSPSIP00000003936.1};
GN Name=PAPPA {ECO:0000313|Ensembl:ENSPSIP00000003936.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000003936.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000003936.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M43B family.
CC {ECO:0000256|ARBA:ARBA00008721}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; AGCU01071893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01071894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01071895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01071896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01071897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01071898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01071899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01071900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01071901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01071902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006121111.1; XM_006121049.2.
DR STRING; 13735.ENSPSIP00000003936; -.
DR MEROPS; M43.004; -.
DR Ensembl; ENSPSIT00000003956.1; ENSPSIP00000003936.1; ENSPSIG00000003723.1.
DR GeneID; 102447252; -.
DR KEGG; pss:102447252; -.
DR CTD; 5069; -.
DR eggNOG; ENOG502QQ7Z; Eukaryota.
DR GeneTree; ENSGT00940000156654; -.
DR HOGENOM; CLU_002636_2_0_1; -.
DR OMA; KQVVCEP; -.
DR OrthoDB; 5483399at2759; -.
DR TreeFam; TF331636; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:Ensembl.
DR GO; GO:0004175; F:endopeptidase activity; IEA:Ensembl.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:Ensembl.
DR CDD; cd00033; CCP; 4.
DR CDD; cd04275; ZnMc_pappalysin_like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 4.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006558; LamG-like.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR011936; Myxo_disulph_rpt.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR043543; PAPPA/PAPPA2.
DR InterPro; IPR008754; Peptidase_M43.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR NCBIfam; TIGR02232; myxo_disulf_rpt; 1.
DR PANTHER; PTHR46130; LAMGL DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46130:SF2; PAPPALYSIN-1; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF05572; Peptidase_M43; 1.
DR Pfam; PF00084; Sushi; 2.
DR SMART; SM00032; CCP; 4.
DR SMART; SM00560; LamGL; 1.
DR SMART; SM00004; NL; 2.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 2.
DR PROSITE; PS50923; SUSHI; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1622
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003901281"
FT DOMAIN 1278..1340
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1409..1469
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 61..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1411..1454
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 1622 AA; 181636 MW; 53169D1A52AAA92D CRC64;
MQLWSLLLPL ALLCTALASG PECGMDERSR RARRDTRHTR QIRYIAPGTC ATRLARGRRS
TAGLEPLPVP RRRQQREVKG EGDSLTPSRA LYFSGQGDQL RLKADIELPR DAFTLQVWLR
AEGGQRSPAV IAGLYDKCSY TSRDRGWVLG INTISDQGNR DPRYFFSLKT DRARKVTTIA
THRSYLPNQW VHLAATYDGH LMKLYVNGAQ VATSGEQMGS IFSLLTLKCK VLMMGGNALN
QNYRGYVEHF SLWRVARSQK EILLDMGQVN HERDTPLPQL VLQESLVNVK KTWSPMKDGS
SPQMEFSYHH GYLLDTSLDP PLCGQTVCDN MEVIASYNKL PRFRHNKVVR YRVVNLYDDK
YQNPTVSRQQ IEFQHQHLNE AFSLYNITWE LEVLDVKNSS LRHRLILANC DISKIGDENC
DPECNHTLTG YDGGDCRHVR HALFHKKKQN GMCDMDCNYE RYNFDGGECC NPEITDVTKT
CFEPDSPYRA YLDVNELKNI LKLDGSTHLN IFFANSTEEE LAGVATWPWD KEALMHLGGI
VLNPSFYGIP GHTHTMIHEI GHSLGLYHVF RGISEILSCS DPCMETEPSF ETGDLCGDTN
PAPKHKLCGD PGPGNDTCGF HSFLNTPYSN FMSYADDDCT NSFTPNQMAR MHCYLDLVYQ
SWQPVKKPAP VAIAPQIVDR TSSSVTLEWF PPIDSHFFER EVGSACDLCT EGRVLVQYAF
GASSPIPCDP SGHWSPREAE GHPDVEQPCK PSVRTWSPNS GVHQHTVPPV CPEPQGCYLE
LEFRYPLIPE SLTVWVTFVS TDWDSSGAVN DIKLLTISGK NISLGPQNIF CDIPLTIKLN
AKQVAEKVYG IQIYTLDEHL EIDAAMLSSI PQSLLCADCR PIQYKVVRDP PFQTGSPFVI
SNLSRRFMDT ELSDSVVYTY QVAVISGTEE SEPSPTTVYI HGSGYCGDGI IQKDLGEDCD
DLNKINGDGC SLFCRQELSF NCLDEPSRCY FHDGDGVCEE FEQMTSIKDC GVYTPKGFID
QWASNVSVSH HSDQACPGWV VIGQPAATQV CRTKVMDLSD VVSQYAWYPC TANFPYSHLT
QTIFWLKAYF SQPMVAAAII VHLVTDGTNY LDQKQETITV QLFDTKKQSH DLGVHVLSCR
NNPLIIPVIH DLSHPFYHTQ AVLISFTSQY VAISGVALRS FHNFDPITIS SCQRGQTYSP
AEKSCVHYSC EASDCQELEI KNAVLNCTSG GFYNGAQCSV SCKTGYILQV QRDDDLVKSQ
LQSSITMTCT DGKWNKQVAC EPVDCQYHVY PATFNCSEGT TFGTKCSFSC RPPALLKGNN
SNLTCMEDGL WSFPEALCEL MCRAPSLIPN ADLQTARCRE DKHKVGSFCK YKCKPGYHVP
GSSRKARKRA FKIQCMQDGT WLAGACVPVT CDPPPSKFHG LYQCTNGFQF NSECRIKCEE
DDHQSGRGHN VIHCRKDGTW SGSFHLCREM QGQCSLPTQL NSNLKLHCAH GYGIGAECIT
SCPDHNESIL LRVNETLQDI QHWMNPQRVK SVVCTAGLKW YPHPALIHCI KACDPFMGDN
YCDAINNRAF CNYDGGDCCT STVKTKKVIP FPMSCDLQAE CACLDPNAQE NSQKDVRSFS
RG
//
