ID K7F7L0_PELSI Unreviewed; 943 AA.
AC K7F7L0;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Integrin subunit alpha 3 {ECO:0000313|Ensembl:ENSPSIP00000004020.1};
GN Name=ITGA3 {ECO:0000313|Ensembl:ENSPSIP00000004020.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000004020.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000004020.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AGCU01067739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01067740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01067741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01067742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01067743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01067744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01067745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01067746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01067747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01067748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 13735.ENSPSIP00000004020; -.
DR Ensembl; ENSPSIT00000004043.1; ENSPSIP00000004020.1; ENSPSIG00000003793.1.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000157746; -.
DR HOGENOM; CLU_004111_1_0_1; -.
DR OMA; ICFAYNQ; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0060076; C:excitatory synapse; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0031527; C:filopodium membrane; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0034667; C:integrin alpha3-beta1 complex; IEA:Ensembl.
DR GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR GO; GO:0048787; C:presynaptic active zone membrane; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0097062; P:dendritic spine maintenance; IEA:Ensembl.
DR GO; GO:0035640; P:exploration behavior; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0030324; P:lung development; IEA:Ensembl.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0048333; P:mesodermal cell differentiation; IEA:Ensembl.
DR GO; GO:0035024; P:negative regulation of Rho protein signal transduction; IEA:Ensembl.
DR GO; GO:0072006; P:nephron development; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0030510; P:regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0030111; P:regulation of Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0097205; P:renal filtration; IEA:Ensembl.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:Ensembl.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR GO; GO:0099560; P:synaptic membrane adhesion; IEA:Ensembl.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF89; INTEGRIN ALPHA-3; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 1.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 884..906
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 221..282
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 384..451
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 599..653
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 788..867
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 943 AA; 100229 MW; 013AC23350A5BEE3 CRC64;
LLAGAPQDVA AGPGNATRTG AVYSCPLSAS VNDCERVAIE EKSTWAPPEV THRRTIASQR
QPAGRVLVSG GLLGYLVSSL SITPRTCLAR HLHQCRANPK ALRLSPGLRG YMDCGSEALP
WATGGQVQWG WMGGQEEEHW PGGGWLWGGR WGEIQRESWD LVDFSYADHD NGNLYIVQGR
GVEKGSGIQQ NRGLVPALPL PPYRVLGXVS LLSNGSQSTL EPSLVLPGEQ VGSYFGSAIA
LADLDSDGWQ DLGAGAPYYF DRKQEAGGAV YVYMNEAGSF RSRASLALMG DLGAPAGWGQ
WSAGGQGGRR VGLEGVAGRC PRGAVAGLRE LRGYGEGRRV GLEGVAGRCP RGAVAGLREE
KGPCCRSCPS RLPLTPASSA PHPSIQVQIC FAYNQSAGDP AYKERITLLY TLEADRDRRP
ARVRFAGSHS AVYKGTFPMP DTKCQDLQLL LLVSRGQCRE GEGALLLAPS PGARLPPRAP
AGSAAGGFAL DLSGGWTGAR GWISLLTMFP CRREGGVSCS PCGREVSLAP GELLDNARGP
GCLPAPQLAL QPGALLLTSA GAGPEQGAGF HSWGLSGDGP GGKLTVTPPP QSGACTFGET
VLCDLGNPFK RNQRAELVVT FEAIGITLDT REVSAQLQLW EGGTQEQLQP VWAALLVDYT
VQASLSMCVS PGARLPERGR GAGPHGSACS GWCPGRSPAG SGLCRAGRPG AGVRVLYRVT
AGRCPRHPGH LQESHVGDSA APGGLAGAAT CLLHPQHSLQ PVFPRVLSSV GGCFPPDAPV
TLATSKKAMS ETLLSCSKGT SRCIWFECPI QDSRHITTIS IRARVWNSTF IEEFRDFDRV
KVDGQATLFL KTHVPTISMK NHTVRFFVDI DSELVEEQPE ESELWLVLVA VGAGLQQLGL
IILLLWKCGF FRRASTRAMY EAKGQKAEMK IQPSETERLT DDY
//
