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Database: UniProt
Entry: K7F8U2_PELSI
LinkDB: K7F8U2_PELSI
Original site: K7F8U2_PELSI 
ID   K7F8U2_PELSI            Unreviewed;       996 AA.
AC   K7F8U2;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   08-NOV-2023, entry version 75.
DE   SubName: Full=SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 {ECO:0000313|Ensembl:ENSPSIP00000004452.1};
GN   Name=SMARCA5 {ECO:0000313|Ensembl:ENSPSIP00000004452.1};
OS   Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC   Trionychidae; Pelodiscus.
OX   NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000004452.1, ECO:0000313|Proteomes:UP000007267};
RN   [1] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG   Soft-shell Turtle Genome Consortium;
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA   White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA   Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA   Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA   Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT   into the development and evolution of the turtle-specific body plan.";
RL   Nat. Genet. 45:701-706(2013).
RN   [3] {ECO:0000313|Ensembl:ENSPSIP00000004452.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
CC       {ECO:0000256|ARBA:ARBA00009687}.
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DR   EMBL; AGCU01144053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01144054; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01144055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01144056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01144057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; K7F8U2; -.
DR   STRING; 13735.ENSPSIP00000004452; -.
DR   Ensembl; ENSPSIT00000004477.1; ENSPSIP00000004452.1; ENSPSIG00000004177.1.
DR   eggNOG; KOG0385; Eukaryota.
DR   GeneTree; ENSGT00940000156733; -.
DR   HOGENOM; CLU_000315_0_3_1; -.
DR   OMA; PRMDEWQ; -.
DR   TreeFam; TF300674; -.
DR   Proteomes; UP000007267; Unassembled WGS sequence.
DR   GO; GO:0016590; C:ACF complex; IEA:Ensembl.
DR   GO; GO:0110016; C:B-WICH complex; IEA:Ensembl.
DR   GO; GO:0005677; C:chromatin silencing complex; IEA:Ensembl.
DR   GO; GO:0000793; C:condensed chromosome; IEA:Ensembl.
DR   GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR   GO; GO:0090536; C:NoRC complex; IEA:Ensembl.
DR   GO; GO:0043596; C:nuclear replication fork; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0016589; C:NURF complex; IEA:Ensembl.
DR   GO; GO:0005721; C:pericentric heterochromatin; IEA:Ensembl.
DR   GO; GO:0031213; C:RSF complex; IEA:Ensembl.
DR   GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR   GO; GO:0090535; C:WICH complex; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR   GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR   GO; GO:0140751; F:histone octamer slider activity; IEA:Ensembl.
DR   GO; GO:0031491; F:nucleosome binding; IEA:InterPro.
DR   GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR   GO; GO:0006281; P:DNA repair; IEA:Ensembl.
DR   GO; GO:0006352; P:DNA-templated transcription initiation; IEA:Ensembl.
DR   GO; GO:1905213; P:negative regulation of mitotic chromosome condensation; IEA:Ensembl.
DR   GO; GO:0016479; P:negative regulation of transcription by RNA polymerase I; IEA:Ensembl.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:Ensembl.
DR   GO; GO:0045740; P:positive regulation of DNA replication; IEA:Ensembl.
DR   GO; GO:0031065; P:positive regulation of histone deacetylation; IEA:Ensembl.
DR   GO; GO:0031062; P:positive regulation of histone methylation; IEA:Ensembl.
DR   GO; GO:0045945; P:positive regulation of transcription by RNA polymerase III; IEA:Ensembl.
DR   GO; GO:0000183; P:rDNA heterochromatin formation; IEA:Ensembl.
DR   GO; GO:0044030; P:regulation of DNA methylation; IEA:Ensembl.
DR   CDD; cd18064; DEXHc_SMARCA5; 1.
DR   CDD; cd00167; SANT; 2.
DR   CDD; cd18793; SF2_C_SNF; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR   Gene3D; 1.20.5.1190; iswi atpase; 1.
DR   Gene3D; 1.10.1040.30; ISWI, HAND domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR015194; ISWI_HAND-dom.
DR   InterPro; IPR036306; ISWI_HAND-dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR017884; SANT_dom.
DR   InterPro; IPR015195; SLIDE.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR   PANTHER; PTHR45623:SF49; ISW-1; 1.
DR   Pfam; PF09110; HAND; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF09111; SLIDE; 1.
DR   Pfam; PF00176; SNF2-rel_dom; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00717; SANT; 2.
DR   SUPFAM; SSF101224; HAND domain of the nucleosome remodeling ATPase ISWI; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51293; SANT; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT   DOMAIN          136..301
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          431..582
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   DOMAIN          784..836
FT                   /note="SANT"
FT                   /evidence="ECO:0000259|PROSITE:PS51293"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          56..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          958..996
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        958..989
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   996 AA;  116619 MW;  13563C62E80D4214 CRC64;
     EMEEGFDDAS PGKQKEIQEP DPTYEEKMQT DRANRFEYLL KQTELFAHFI QPAAQKTPTS
     PLKMKPGRPR IKKDEKQNLL SVGDYRHRRT EQEEDEELLT ESSKATNVCT RFEDSPSYVK
     WGKLRDYQVR GLNWLISLYE NGINGILADE MGLGKTLQTI SLLGYMKHYR NIPGPHMVLV
     PKSTLHNWMS EFKRWVPTLK AVCLIGDKDQ RAAFVRDVLL PGEWDVCVTS YEMLIKEKSV
     FKKFNWRYLV IDEAHRIKNE KSKLSEIVRE FKTTNRLLLT GTPLQNNLHE LWALLNFLLP
     DVFNSADDFD SWFDTNNCLG DQKLVERLYI VLRPFLLRRI KADVEKSLPP KKEVKIYVGL
     SKMQREWYTR ILMKDIDILN SAGKLDKMRL LNILMQLRKC CNHPYLFDGA EPGPPYTTDM
     HLVTNSGKMV VLDKLLPKLK EQGSRVLIFS QMTRVLDILE DYCMWRNYEY CRLDGQTPHD
     ERQASINAYN EPGSSKFVFM LSTRAGGLGI NLATADVVIL YDSDWNPQVD LQAMDRAHRI
     GQTKTVRVFR FITDNTVEER IVERAEMKLR LDSIVIQQGK CGLEILKMLT RNDRLQMIRH
     GATHVFASKE SEITDEDIDG ILERGAKKTA EMNEKLSKMG ESSLRNFTMD TESSVYNFEG
     EDYREKQKMA FTEWIEPPKR ERKANYAVDA YFREALRVSE PKAPKAPRPP KQPNVQDFQF
     FPPRLFELLE KEILYYRKTI GYKVPRNPDL PNAAQAQKEE QLKIDEADPL NDEELEEKEK
     LLTQGFTNWN KRDFNQFIKA NEKWGRDDIE NIAREVEGKT PEEVIEYSAV FWERCNELQD
     IEKIMAQIER GEARIQRRIS IKKALDTKNC NGTHFHQLRI SYGTNKGKNY TEEEDRFLIC
     MLHKLGFDKE NVYDELRQCI RNSPQFRFDW FLKSRTAMEL QRRCNTLITL IERENMELEE
     KEKAEKKKRG PKPSSAQKRK MDGTPDGRGR KKKLKL
//
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