ID K7FAH7_PELSI Unreviewed; 890 AA.
AC K7FAH7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=UNC5C {ECO:0000313|Ensembl:ENSPSIP00000005037.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000005037.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000005037.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR EMBL; AGCU01012099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FAH7; -.
DR Ensembl; ENSPSIT00000005066.1; ENSPSIP00000005037.1; ENSPSIG00000004662.1.
DR GeneTree; ENSGT00950000182815; -.
DR HOGENOM; CLU_014383_0_0_1; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08799; Death_UNC5C; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR042154; Death_UNC5C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF7; NETRIN RECEPTOR UNC5C; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 336..361
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 134..215
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 489..623
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
SQ SEQUENCE 890 AA; 99288 MW; 5C66D3F1FDBD4872 CRC64;
DDDFFHELPE TFPSDPPEPL PHFLIEPEEA YIVKNKPVNL YCKASPATQI YFKCNSEWVH
QKDHVVDERV DETSGLIVRE VSIEISRQQV EELFGPEDYW CQCVAWSSAG TTKSRKAYVR
IAYLRKTFEQ EPLGKEVSLE QEVLLQCRPP EGIPVAEVEW LKNEEVIDPV EDRNFYITID
HNLIIKQARL SDTANYTCVA KNIVAKRKST TATVIVYVNG GWSTWTEWSV CNGRCGRGYQ
KRTRTCTNPA PLNGGAFCEG QSVQKITCTT LCPVDGRWTA WSKWSTCGTE CTHWRRRECT
APAPKNGGKD CEGLVLQSKN CTDGLCMQTA PDSDDVALYV GIVIAVIVCL AISVIVALFV
YRKNHRDFES DIIDSSALNG GFQPVNIKAA RQDLLAVPPD LTSAAAMYRG PVYALHDVSD
KIPMTNSPIL DPLPNLKIKV YNTSGAVTPQ DDLSDFSSKL SPQITQSLLE NETLNMKNQS
LARQTDPSCT AFGTFNSLGG HLIIPNSGVS LLIPAGAVPQ GRVYEMYLTV HRKENMRPPV
EDSQTLLTPV VSCGPPGALL TRPVILTMHH CAEPNTEDWK IQLKNQAAQG QWEDVVMVGE
ENFTTPCYIQ LDPESCHILT ETLSTYALVG QSTNKTAAKR LKLAIFGPLS CSSLEYNIRV
YCLDDTQDAL KEVLQLERQM GGQLLEEPKA LHFKGSTHNL RLSIHDIAHS LWKSKLLAKY
QEIPFYHIWS GCQRNLHCTF TLERFSLSTL ELVCKLCVRQ VEGEGQIFQL NCTVSEEPTG
IDYPLMDSGS TITTIVGPSA FSIPLPIRQK LCSSLDAPQT RGHDWRMLAH KLKLDRYLNY
FATKSSPTGV ILDLWEAQNF PDGNLSMLAA VLEEMGRHET VVSLAAEGKY
//
