ID K7FAP2_PELSI Unreviewed; 1271 AA.
AC K7FAP2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Dynein axonemal heavy chain 8 {ECO:0008006|Google:ProtNLM};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000005102.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000005102.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01109577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01109578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01109579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01109580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01109581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01109582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01109583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01109584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01109585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FAP2; -.
DR STRING; 13735.ENSPSIP00000005102; -.
DR Ensembl; ENSPSIT00000005131.1; ENSPSIP00000005102.1; ENSPSIG00000004754.1.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000158992; -.
DR HOGENOM; CLU_000038_1_0_1; -.
DR OMA; WERTINE; -.
DR TreeFam; TF343076; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961:SF14; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 7..193
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 221..441
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 687..796
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 827..966
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 973..1268
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 75..123
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1271 AA; 145643 MW; 53788CBD530BDC9D CRC64;
QLMSGPFLQS LQQFAKDSIN EETVELLQPY FNMEDYTFEN GKKVCGNVAG LLSWTQAMAT
FYGINREVLP LKSNLAKQEG RLKVANAELA TAQALLDEKQ AELDKVQAKF DAAMKEKMDL
LNDADVCRRK MQAASALIDG LSGEKVRWTQ QSKEFKAQIN RLVGDVLLCT GFLSYCGPFN
QIFRNLLLKD LWEAEMRIRK IPFTENLNLI SMLVDQPTIS EWNLQGLPGD ELSIQNGIIV
TKATRYPLLI DPQTQGKTWI KQKEKGNELQ VTTLNHKYFR THLEDSLSLG RSLVIEDIAE
ELDPALDNIL EKNFIKSGTS FKVKVGDKEV EVMTSFKLYI TTKLPNPAFT PEINAKTSVI
DFTVTMKGLE NQLLKRVILT EKQELEGERI KLMEDVTFNK RKMKELEDNL LYKLSATKGS
LVDDESLIGV LRTTKQTAAE VSEKLYVAAE TQVKINTAQE EYRPAATRGS ILYFLITEMS
MVNNMYQTSL AQFLRLFDHS MAKSEKSPLP QKRISNIIEY LTFETFTYSV RGLYEDHKFL
FTILLTLKID LQRGQVKPKE FQALIKGGAA LDLKACPPKP FRWILDMTWL NLVELSKLPQ
FAEIMNQVSR NEKGWKSWFD KDAPEEEVIP DGYNDSLDTC RKLLLIRSWC PDRTLSQARK
YIGDSLDDKY TEPVILNLEK TWEESDTRTP LICFLSMGSD PTIQIDALAR KLKLECRAIS
MGQGQEVHAR KLTQMSMQQG GWVLLQNCHL GLDFMDELLE TLLTAEIPDE SFRVWITTEP
HDKFPITLLQ VSIKFTNEPP QGVRAGLKRT FSGINQDLLD VSNMPMWKPL LYTVAFLHST
VQERRKFGPL GWNIPYEFNS ADFTASVQFI QNHLDECDIK KGISWSTVRY MIGEVQYGGR
VTDDFDKRLL NCFARVWFSE KMFESTFCFY TGYKIPVCKT LDQYQEYIQT LPAMDSPEVF
GLHPNADITY QSNTAANVLD TITNIQPKES GGGAGETREA IVYRLAEDML DKLPPDYIPH
EVKARLIKMG HLNSMNIFLR QEIDRMQKVI TILRNSLNDL KLAIEGTIIM SENLRDALDN
MYDARIPQLW KRVSWDSSTL GFWFTELLER NTQFFTWIFE GRPNVFWMTG FFNPQGFLTA
MRQEATRAHK GWALDTVTIH NEVLKQSKEE ITTPPPEGVY IYGLYLDGAG WDRRNSKLTE
PTPKILFTVL PVVHVFAINT TGPKDPKLYV CPIYKKPRRT DLTFITVIYL RTIVSPDHWI
LRGVALLCDI K
//
