UniProt: K7FCF6

Database: UniProt
Entry: K7FCF6_PELSI

LinkDB:  K7FCF6_PELSI 
Original site:  K7FCF6_PELSI

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Ontology (63)   
   GO (63)   
Gene (3)   
   ENSEMBL-UP (3)   
DNA sequence (3)   
   EMBL (3)   
Protein domain (10)   
   InterPro (6)   
   Pfam (2)   
   PROSITE (1)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (80)   

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ID   K7FCF6_PELSI            Unreviewed;       584 AA.
AC   K7FCF6;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Heterogeneous nuclear ribonucleoprotein U {ECO:0000313|Ensembl:ENSPSIP00000005716.1};
GN   Name=HNRNPU {ECO:0000313|Ensembl:ENSPSIP00000005716.1};
OS   Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC   Trionychidae; Pelodiscus.
OX   NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000005716.1, ECO:0000313|Proteomes:UP000007267};
RN   [1] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG   Soft-shell Turtle Genome Consortium;
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA   White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA   Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA   Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA   Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT   into the development and evolution of the turtle-specific body plan.";
RL   Nat. Genet. 45:701-706(2013).
RN   [3] {ECO:0000313|Ensembl:ENSPSIP00000005716.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; AGCU01167272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01167273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01167274; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; K7FCF6; -.
DR   STRING; 13735.ENSPSIP00000005716; -.
DR   Ensembl; ENSPSIT00000005749.1; ENSPSIP00000005716.1; ENSPSIG00000005253.1.
DR   eggNOG; KOG2242; Eukaryota.
DR   GeneTree; ENSGT00940000156546; -.
DR   HOGENOM; CLU_012140_0_0_1; -.
DR   OMA; APKMETE; -.
DR   TreeFam; TF317301; -.
DR   Proteomes; UP000007267; Unassembled WGS sequence.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IEA:Ensembl.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0070937; C:CRD-mediated mRNA stability complex; IEA:Ensembl.
DR   GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0032839; C:dendrite cytoplasm; IEA:GOC.
DR   GO; GO:0098577; C:inactive sex chromosome; IEA:Ensembl.
DR   GO; GO:0000776; C:kinetochore; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:1990498; C:mitotic spindle microtubule; IEA:Ensembl.
DR   GO; GO:1990023; C:mitotic spindle midzone; IEA:Ensembl.
DR   GO; GO:0000228; C:nuclear chromosome; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl.
DR   GO; GO:0005697; C:telomerase holoenzyme complex; IEA:Ensembl.
DR   GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR   GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl.
DR   GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0106222; F:lncRNA binding; IEA:Ensembl.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:Ensembl.
DR   GO; GO:0008143; F:poly(A) binding; IEA:Ensembl.
DR   GO; GO:0017130; F:poly(C) RNA binding; IEA:Ensembl.
DR   GO; GO:0034046; F:poly(G) binding; IEA:Ensembl.
DR   GO; GO:0036002; F:pre-mRNA binding; IEA:Ensembl.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:Ensembl.
DR   GO; GO:0099122; F:RNA polymerase II C-terminal domain binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR   GO; GO:0017069; F:snRNA binding; IEA:Ensembl.
DR   GO; GO:0070034; F:telomerase RNA binding; IEA:Ensembl.
DR   GO; GO:0001097; F:TFIIH-class transcription factor complex binding; IEA:Ensembl.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR   GO; GO:1990845; P:adaptive thermogenesis; IEA:Ensembl.
DR   GO; GO:0055013; P:cardiac muscle cell development; IEA:Ensembl.
DR   GO; GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:Ensembl.
DR   GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR   GO; GO:0032922; P:circadian regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0070934; P:CRD-mediated mRNA stabilization; IEA:Ensembl.
DR   GO; GO:0098963; P:dendritic transport of messenger ribonucleoprotein complex; IEA:Ensembl.
DR   GO; GO:0009048; P:dosage compensation by inactivation of X chromosome; IEA:Ensembl.
DR   GO; GO:0051457; P:maintenance of protein location in nucleus; IEA:Ensembl.
DR   GO; GO:0016071; P:mRNA metabolic process; IEA:Ensembl.
DR   GO; GO:1900152; P:negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; IEA:Ensembl.
DR   GO; GO:2000737; P:negative regulation of stem cell differentiation; IEA:Ensembl.
DR   GO; GO:0032211; P:negative regulation of telomere maintenance via telomerase; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0034244; P:negative regulation of transcription elongation by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:1902425; P:positive regulation of attachment of mitotic spindle microtubules to kinetochore; IEA:Ensembl.
DR   GO; GO:0090336; P:positive regulation of brown fat cell differentiation; IEA:Ensembl.
DR   GO; GO:2000767; P:positive regulation of cytoplasmic translation; IEA:Ensembl.
DR   GO; GO:2000648; P:positive regulation of stem cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:1902889; P:protein localization to spindle microtubule; IEA:Ensembl.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:Ensembl.
DR   GO; GO:1902275; P:regulation of chromatin organization; IEA:Ensembl.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:1901673; P:regulation of mitotic spindle assembly; IEA:Ensembl.
DR   GO; GO:1990280; P:RNA localization to chromatin; IEA:Ensembl.
DR   CDD; cd12884; SPRY_hnRNP; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035778; SPRY_hnRNP_U.
DR   PANTHER; PTHR12381:SF11; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U; 1.
DR   PANTHER; PTHR12381; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER; 1.
DR   Pfam; PF13671; AAA_33; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT   DOMAIN          38..242
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          426..508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          528..558
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        426..444
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   584 AA;  65681 MW;  45E92D3EE0963E1B CRC64;
     GDTKTEQKPG DKKRGVKRPR EDHGRGYFEY IEENKYSRAK SPQPPVEEED EQFDDTMVCL
     DTYNCDLHFK ISRDRFSASS LTMESFAFLW AGGRASYGVS TGKVCFEMKV TEKIPVKHLY
     TKDIDIHEVR VGWSLNSSGM LLGEEEFSYG YSLKGIKTCN CETEDFGEKF DENDVIGCFA
     NFEGDEVELS YSKNGQDLGV AFKISKDHNC AIEFNFGQKD EPYFPIPEEF SLIQKVPLED
     RVRGPKGPDH KKDCEVVMMI GLPGAGKTTW VTKHAAANPG KYNILGTNTI MDKMMVAGFK
     RQMADTGKLN TLLQRAPQCL GKFIEIAARK KRNFILDQTN VSAAAQRRKM CLFAGFQRKA
     VVVCPNDEDY KQRTQKKAEV EGKDLPEHAV LKMKGNFTLP EVAECFDEIT YVELQKEEAQ
     KLLEQYKEES KKSLPPEKKQ NTGSKKSNKK SGKNQFNRGG QRGRGGFNMR GNFRGGVPGN
     RGGYNRRGGN MPQRGGGGGG GGGGSGAIGY PYPRGPVFPS RGGYSNRGNY NRGGMPNRGN
     YNQNFRGRGN NRGYKNQSQG YNQWQQGQFW GQKPWSQHYH QGYY
//

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