ID K7FGV1_PELSI Unreviewed; 714 AA.
AC K7FGV1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Ribosomal protein S6 kinase alpha-6 {ECO:0000313|Ensembl:ENSPSIP00000007261.1};
GN Name=RPS6KA6 {ECO:0000313|Ensembl:ENSPSIP00000007261.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000007261.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000007261.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC protein kinase family. S6 kinase subfamily.
CC {ECO:0000256|ARBA:ARBA00009804}.
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DR EMBL; AGCU01135598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01135599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01135600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01135601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01135602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01135603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01135604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01135605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01135606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006130511.1; XM_006130449.2.
DR AlphaFoldDB; K7FGV1; -.
DR STRING; 13735.ENSPSIP00000007261; -.
DR Ensembl; ENSPSIT00000007302.1; ENSPSIP00000007261.1; ENSPSIG00000006547.1.
DR eggNOG; KOG0603; Eukaryota.
DR GeneTree; ENSGT00940000159242; -.
DR HOGENOM; CLU_000288_58_3_1; -.
DR OMA; HSWITCK; -.
DR OrthoDB; 5489497at2759; -.
DR TreeFam; TF313438; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14177; STKc_RSK4_C; 1.
DR CDD; cd05582; STKc_RSK_N; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR017892; Pkinase_C.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR016239; Ribosomal_S6_kinase_II.
DR InterPro; IPR041906; RSK_N.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24351; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR PANTHER; PTHR24351:SF246; RIBOSOMAL PROTEIN S6 KINASE ALPHA-6; 1.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF00433; Pkinase_C; 1.
DR PIRSF; PIRSF000606; Ribsml_S6_kin_2; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000606-
KW 51}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR000606-51};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 41..300
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 301..370
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT DOMAIN 395..652
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 166
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-50"
FT ACT_SITE 512
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-50"
FT BINDING 47..55
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-51"
FT BINDING 73
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-51,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 401..409
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-51"
FT BINDING 424
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-51,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 714 AA; 80638 MW; 01288436771D1D46 CRC64;
MVDEPMEEGE PYSYNDEGNV KEIPITHHVK EGCEKADPAQ FELLKVLGQG SFGKVFLVRK
IIGPDAGQLY AMKVLKKASL KVRDRVRTKM ERDILVEVNH PFIVKLHYAF QTEGKLYLIL
DFLRGGDVFT RLSKEVMFTE EDVKFYLAEL ALALDHLHSL GIVYRDLKPE NILLDEAGHI
KLTDFGLSKE SVDQEKKAYS FCGTVEYMAP EVVNRRGHNQ SADWWSFGVL MFEMLTGTLP
FQGKDRNETM NMILKAKLGM PQFLSPEAQS LLRMLFKRNP SNRLGAGSDG VEEIKRHPFF
STVDWNKLFR REIQPPFKPA SGKPEDTFCF DPEFTAKTPK DSPGVPPSAN AHQLFKGFSF
VATTAIEDHK ISPLTNILPI VQQLHGNSAQ FTDVYELKED IGVGSYSVCK RCVHIATNME
FAVKIIDKSK RDPSEEIEIL MRYGQHPNII TLKDVYDDGR CIYLVTELMK GGELLDRILR
QKYFSEREAS AVLYTITKTV DYLHCQGVVH RDLKPSNILY MDDSSNADSI RICDFGFAKQ
LRGENGLLLT PCYTANFVAP EVLMRQGYDA ACDIWSLGVL LYTMLAGYTP FANGPNDTPE
EILLRIGSGK FSLSGGNWDT VSDAAKDLLS HMLHVDPHQR YTAEQVLKHS WIACRDQLPH
YQLNRQDAPH LVKGAMAATY SALNHKTFQP VLEPVAASSL AQRRSMKKLT STDL
//
