ID K7FIC7_PELSI Unreviewed; 414 AA.
AC K7FIC7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Lipase {ECO:0000256|PIRNR:PIRNR000862};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000007787.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000007787.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|PIRNR:PIRNR000862}.
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DR EMBL; AGCU01074772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01074773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FIC7; -.
DR STRING; 13735.ENSPSIP00000007787; -.
DR Ensembl; ENSPSIT00000007828.1; ENSPSIP00000007787.1; ENSPSIG00000007101.1.
DR eggNOG; KOG2624; Eukaryota.
DR GeneTree; ENSGT00940000156860; -.
DR HOGENOM; CLU_010974_0_0_1; -.
DR OMA; WGLNVKE; -.
DR TreeFam; TF315485; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR025483; Lipase_euk.
DR PANTHER; PTHR11005:SF12; LIPASE MEMBER M; 1.
DR PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PIRSF; PIRSF000862; Steryl_ester_lip; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR000862};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963,
KW ECO:0000256|PIRNR:PIRNR000862};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 95..395
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
FT ACT_SITE 189
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 360
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 389
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
SQ SEQUENCE 414 AA; 47207 MW; 67E542871984FCD3 CRC64;
RATLLTGECS VLHRTKMWLF ITVAYLLQAT VSPEGLKRVK RDHVDPEAYM NISELITYRG
YPSEEYEVVT EDGYILNINR IPYGIENQGN TVVKPAVFLQ HGLLGDASNW VTNLANNSLG
FILADAGYDV WMGNNRGNTW SRRHMNLSVE KEEFWSFSFD EMAKFDLPAV LNFIMQKTGQ
EQLYYVGYSQ GATIALITFS TMPQLAKRIK LYFALAPVTT VKYARSPAVK LLHLPEMLLR
GLLGRKELFH QSEWLRKLIV SFCGHSIFAK LCGNVFFILG GYNVNNINMS RVNVYVARAP
AGTSAQNIIH WSQIVHSGEF QAYNWRSRTK NMAKYAQATP PLYKIKDMTV PTAIWTGGKD
LLADLKDINI LLPQIINLVH YKNIPEWAHL DFIWGLDAPL RMYNEIVDLM EKNP
//
